Age-dependent degeneration of the stria vascularis in human cochleae
Age-dependent degeneration of the stria vascularis in human cochleae
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DOI：
10.1097/01.mlg.0000234940.33569.39
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发表时间：
2006-10-01
期刊：
影响因子：
2.6
通讯作者：
Omori, Koichi
中科院分区：
文献类型：
--
作者：
Suzuki, Teruhisa;Nomoto, Yukio;Omori, Koichi
目的：年龄增长是后天性听力损伤的常见原因。本研究探讨了人耳蜗与年龄相关的形态学变化，特别关注血管纹（SV）和螺旋神经节（SG）的退化。研究设计：回顾性病例分析。研究方法：研究组包括91个年龄在10到85岁之间的个体的颞骨，这些个体没有提示耳蜗变性的特定原因的病史或听力检查结果。我们量化SV和SG萎缩在每个耳蜗轮使用形态测量。SV和SG萎缩与年龄、听力损失的听力测定模式和听阈的相关性进行了统计学研究。结果. SV和SG均显示出随着年龄增长而进行性萎缩的趋势。然而，统计学显着的相关性之间观察到老化和SV萎缩，只有在顶端和基底耳蜗转。这些发现与先前在沙鼠中报道的结果一致。SV或SG萎缩与听力检查结果之间无显著相关性。结论：SV萎缩是老年人耳蜗最显著的解剖学特征。
Objective: Aging is a common cause of acquired hearing impairments. This study investigated age-related morphologic changes in human cochleae, with a particular focus on degeneration of the stria vascularis (SV) and the spiral ganglion (SG). Study Design: Retrospective case review. Methods: The study group comprised 91 temporal bones from individuals aged 10 to 85 years who had no history or audiometric findings suggestive of specific causes of cochlear degeneration. We quantified the SV and SG atrophy at each cochlear turn using morphometric measurements. Correlations of the SV and SG atrophy with age, audiometric patterns of hearing loss, and auditory thresholds were statistically investigated. Result. The SV and the SG both showed a tendency for progressive atrophy to develop with age. However, statistically significant correlations were observed between aging and SV atrophy only in the apical and basal cochlear turns. These findings were consistent with those reported previously in gerbils. No significant correlations were detected between SV or SG atrophy and audiometric findings. Conclusion: SV atrophy appears to be the most prominent anatomic characteristic of aged human cochleae.