Controlled Delivery Using Oligonucleotide-Capped Mesoporous Silica Nanoparticles
Controlled Delivery Using Oligonucleotide-Capped Mesoporous Silica Nanoparticles
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DOI：
10.1002/anie.201001847
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发表时间：
2010-01-01
影响因子：
16.6
通讯作者：
Amoros, Pedro
中科院分区：
文献类型：
--
作者：
Climent, Estela;Martinez-Manez, Ramon;Amoros, Pedro
方案1.用3-氨丙基三乙氧基硅烷官能化并以单链寡核苷酸(O1)封端的门控材料S1的表示。包裹的客体(荧光素)的输送是在互补寡核苷酸(O2)存在的情况下选择性地完成的。显示了寡核苷酸O1和O2的序列。
Scheme 1. Representation of the gated material S1 functionalized with 3-aminopropyltriethoxysilane and capped with a single-stranded oligonucleotide (O1). The delivery of the entrapped guest (fluorescein) is selectively accomplished in the presence of the complementary oligonucleotide (O2). The sequence of the oligonucleotides O1 and O2 is shown.