Room temperature hydroamination of N-alkenyl ureas catalyzed by a gold(I) N-heterocyclic carbene complex
Room temperature hydroamination of N-alkenyl ureas catalyzed by a gold(I) N-heterocyclic carbene complex
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DOI：
10.1021/ol062107i
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发表时间：
2006-11-09
期刊：
影响因子：
5.2
通讯作者：
Widenhoefer, Ross A.
中科院分区：
文献类型：
--
作者：
Bender, Christopher F.;Widenhoefer, Ross A.
在室温或接近室温下用金（I）N，N-二芳基咪唑-2-亚基络合物和AgOTf的催化1：1混合物处理N-4-戊烯基或N-5-己烯基脲导致分子内外氢化胺化，以优异的产率形成相应的氮杂环。
[GRAPHICS]Treatment of an N-4-pentenyl or N-5-hexenyl urea with a catalytic 1: 1 mixture of a gold(I) N,N-diarylimidazol-2-ylidine complex and AgOTf at or near room temperature leads to intramolecular exo-hydroamination to form the corresponding nitrogen heterocycle in excellent yield.