Neurofibrillary degeneration induced by vincristine therapy.
Neurofibrillary degeneration induced by vincristine therapy.
复制标题
长春新碱治疗引起的神经原纤维变性。
DOI：
10.1001/archneur.1969.00480080099012
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发表时间：
1969
影响因子：
--
通讯作者：
H. Wisniewski
中科院分区：
文献类型：
--
作者：
M. Shelanski;H. Wisniewski
硫酸长春新碱和硫酸长春新碱是从长春花属植物长春花中分离得到的二聚体生物碱。事实证明，这两种药物在诱导白血病缓解方面都很有用，无论是单独使用还是与其他药物联合使用。然而，使用它们往往伴随着神经和肌肉损伤的证据。最常见的发现是感觉障碍，1手指和脚趾的麻木和异常感，2下肢深肌腱反射的丧失，伸肌无力，足下垂和共济失调。3，4在某些情况下，这种神经病已被报告为可逆的，2而在其他情况下没有明显的可逆。3Moress和他的同事1最近报告了3例与长春新碱治疗相关的严重和不可逆的神经病。这些患者的周围神经可见不同程度的轴突变性和髓鞘丢失。肌肉中球膜体的发育
VINCRISTINE sulfate and vinblastine sulfate are dimeric alkaloids isolated from the periwinkle plant, Vinca rosea. Both of these agents have proven useful in inducing remission in leukemia, either alone or in concert with other agents. Their use, however, is often accompanied by evidence of nerve and muscle damage. The most common findings are dysesthesias,1anesthesia, and parasthesias in the fingers and toes,2loss of deep tendon reflexes in the lower extremities, weakness of extensors, foot drop, and ataxia.3,4In some cases this neuropathy has been reported to be reversible,2while in others no reversibility has been evident.3Moress and his co-workers1have recently reported three cases in which severe and irreversible neuropathy was associated with vincristine therapy. A varying degree of axonal degeneration and myelin loss was seen in the peripheral nerves of these patients. The development of spheromembranous bodies in the muscles