The Influence of Environmental Enrichment on Cardiovascular and Behavioral Responses to Social Stress.
The Influence of Environmental Enrichment on Cardiovascular and Behavioral Responses to Social Stress.
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环境丰富对心血管和社会压力行为反应的影响。
DOI：
10.1097/psy.0000000000000558
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发表时间：
2018-04
影响因子：
3.3
通讯作者：
Grippo AJ
中科院分区：
文献类型：
--
作者：
Normann MC;McNeal N;Dagner A;Ihm E;Woodbury M;Grippo AJ
压力与负面的心血管后果和抑郁行为的增加有关。环境丰富（EE）涉及接触新的项目，提供身体和认知刺激。EE具有行为，认知和神经生物学效应，可能会改善人类和动物模型的应激反应。本研究探讨了EE对雌性草原田鼠在社会应激后行为和心血管功能的潜在保护作用。在整个研究过程中，将无线电遥测发射器植入雌性草原田鼠以测量心率（HR）和心率变异性（HRV）。所有雌性动物都与雄性伴侣配对5天，然后与伴侣分开5天，并进行为期10天的治疗。治疗包括继续隔离、与EE隔离或与伴侣重新配对（每组n=9）。给药后，在强迫游泳试验（FST）中观察动物的压力应对行为。相对于基线，隔离使所有组的HR升高，HRV降低[p < .001]。EE组和重新配对组的HR和HRV恢复到基线水平，但继续隔离组的HR和HRV没有恢复到基线水平[p < .001]。相对于继续隔离组，EE组和重新配对组中的动物在FST期间显示出显著更低的不动时间[p < .001]和HR [p < .03]，并且在FST之后HR返回到基线水平的潜伏期更短[p < .001]。EE和修复配对逆转了与社会隔离相关的负面行为和心血管后果。
Stress is linked to negative cardiovascular consequences and increases in depressive behaviors. Environmental enrichment (EE) involves exposure to novel items that provide physical and cognitive stimulation. EE has behavioral, cognitive, and neurobiological effects that may improve stress responses in humans and animal models. This study investigated the potential protective effects of EE on behavior and cardiovascular function in female prairie voles following a social stressor. Radiotelemetry transmitters were implanted into female prairie voles to measure heart rate (HR) and heart rate variability (HRV) throughout the study. All females were paired with a male partner for five days, followed by separation from their partner for five additional days, and a ten-day treatment period. Treatment consisted of either continued isolation, isolation with EE, or re-pairing with the partner (n=9 per group). Following treatment, animals were observed in the forced swim test (FST) for measures of stress coping behaviors. Isolation elevated HR and reduced HRV relative to baseline for all groups [p < .001]. HR and HRV returned to baseline in the EE and re-paired groups, but not in the continued isolation group [p < .001]. Animals in the EE and re-paired groups displayed significantly lower immobility time [p < .001] and HR [p < .03] during the FST, with a shorter latency for HR to return to baseline levels following the FST, relative to the continued isolation group [p < .001]. EE and re-pairing reversed the negative behavioral and cardiovascular consequences associated with social isolation.