Chiral imprinting of diblock copolymer single-chain particles.
Chiral imprinting of diblock copolymer single-chain particles.
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DOI：
10.1021/la2006887
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发表时间：
2011-04
期刊：
影响因子：
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通讯作者：
G. Njikang;Guojun Liu;Liangzhi Hong
中科院分区：
文献类型：
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作者：
G. Njikang;Guojun Liu;Liangzhi Hong
本文报道了半径为~ 3.7 nm的聚合物单链颗粒的分子印迹。为此，使用模板L-苯丙氨酸苯胺或L-ΦAA和二嵌段共聚物PtBA-b-P（cma -r- ca）。这里，PtBA表示聚丙烯酸叔丁酯，P（cma -r-CA）表示由肉桂酰氧乙基甲基丙烯酸酯（CEMA）和羧基承载（CA）单元组成的随机块。在CHCl(3)/环己烷（CHX）中，CHX体积%为64vol %或f(CHX) = 64%时，PtBA-b- p （cma -r- ca）为块体选择性溶剂，形成球形胶束。核心由不溶性P（cma -r-CA）和与CA基团络合的L-ΦAA组成。将胶束溶液以f(CHX) = 64%的速度缓慢泵入搅拌过的CHCl(3)/(CHX)中，引发胶束解离成单链胶束，该胶束可能由溶解的PtBA尾部和坍塌的P(cma -r- ca)/L-ΦAA头组成。由于溶剂库在持续的紫外照射下，P（cma -r- ca）头部的光交联单元交联，单链胶束转化为交联单链胶束或蝌蚪。同步胶束添加和光反应速率允许从该方案中制备高最终聚合物浓度的基本纯蝌蚪。从蝌蚪头部提取L-ΦAA后获得印迹蝌蚪。在优化条件下，印迹蝌蚪对L-ΦAA具有很高的结合能力和选择性。此外，颗粒对L-ΦAA的释放和再结合速率也很高。
This Article reports the molecular imprinting of polymer single-chain particles that have a radius ∼3.7 nm. For this, the template L-phenylalanine anilide or L-ΦAA and a diblock copolymer PtBA-b-P(CEMA-r-CA) were used. Here, PtBA denotes poly(tert-butyl acrylate), and P(CEMA-r-CA) denotes a random block consisting of cinnamoyloxyethyl methacrylate (CEMA) and carboxyl-bearing (CA) units. In CHCl(3)/cyclohexane (CHX) with 64 vol % of CHX or at f(CHX) = 64%, a block-selective solvent for PtBA, PtBA-b-P(CEMA-r-CA) formed spherical micelles. The core consisted of the insoluble P(CEMA-r-CA) block and L-ΦAA, which complexed with the CA groups. Pumping slowly this micellar solution into stirred CHCl(3)/(CHX) at f(CHX) = 64% triggered micelle dissociation into single-chain micelles, which comprised presumably a solubilized PtBA tail and a collapsed P(CEMA-r-CA)/L-ΦAA head. Because the solvent reservoir was under constant UV irradiation, the photo-cross-linkable units in the P(CEMA-r-CA) head cross-linked, and the single-chain micelles were converted into cross-linked single-chain micelles or tadpoles. Synchronizing the micelle addition and photoreaction rates allowed the preparation, from this protocol, of essentially pure tadpoles at high final polymer concentrations. Imprinted tadpoles were procured after L-ΦAA was extracted from the tadpole heads. Under optimized conditions, the produced imprinted tadpoles had exceptionally high binding capacity and high selectivity for L-ΦAA. In addition, the rates of L-ΦAA release from and rebinding by the particles were high.