Boronic acid-based fluorescent receptors for selective recognition of thymine glycol
Boronic acid-based fluorescent receptors for selective recognition of thymine glycol
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DOI：
10.1016/j.tetlet.2008.07.173
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发表时间：
2008-10-13
影响因子：
1.8
通讯作者：
Vasseur, Jean-Jacques
中科院分区：
文献类型：
--
作者：
Luvino, Delphine;Gasparutto, Didier;Vasseur, Jean-Jacques
胸腺嘧啶乙二醇是胸腺嘧啶的主要氧化产物。细胞DNA中胸腺嘧啶乙二醇的含量是氧化损伤程度的一个标志，因此胸腺嘧啶乙二醇的化学传感器具有许多潜在的应用。在我们继续致力于检测修饰核苷的研究中，我们在这里报告了我们使用硼酸传感器在核苷和寡核苷酸水平上荧光检测胸腺嘧啶乙二醇的结果。这些受体在与胸腺嘧啶乙二醇结合的水溶液条件下显示出显著的荧光增强和高选择性。(C) 2008 Elsevier Ltd版权所有。
Thymine glycol is the major oxidation product of thymine. The amount of thymine glycol present within cellular DNA is one marker of the extent of oxidative damage, and chemosensors for thymine glycol have therefore a number of potential applications. In continuation of our studies devoted to the detection of modified nucleosides, we report herein our results toward the fluorescence detection of thymine glycol at both the nucleoside and the oligonucleotide levels using boronic acid sensors. These receptors show significant fluorescence enhancements and high selectivities in aqueous conditions upon binding with thymine glycol. (C) 2008 Elsevier Ltd. All rights reserved.