Variables associated with anticipatory nausea and vomiting in pediatric cancer patients receiving ondansetron antiemetic therapy.
Variables associated with anticipatory nausea and vomiting in pediatric cancer patients receiving ondansetron antiemetic therapy.
复制标题
与接受昂丹司琼止吐治疗的儿科癌症患者预期恶心和呕吐相关的变量。
DOI：
10.1093/jpepsy/22.1.45
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发表时间：
1997
影响因子：
3.6
通讯作者：
Bieberich,AA
中科院分区：
文献类型：
--
作者：
Tyc,VL;Mulhern,RK;Barclay,DR;Smith,BF;Bieberich,AA
调查了59例常规接受昂丹司琼（Zofran®）止吐治疗的儿童癌症患者中预期恶心和呕吐（ANV）的患病率，并确定了与ANV相关的患者相关因素。在样本中，59%的人表示至少有轻微的ANV症状，这表明尽管使用了枢复宁，但仍有相当数量的患者报告ANV并受到其困扰。将这些儿童与那些没有ANV症状的儿童进行比较。虽然认知过程也可能起作用，但大多数ANV的病理学与传统的经典条件反射模型一致。对化疗后严重呕吐有更高期望的儿童和那些因恶心和呕吐而更痛苦的儿童更容易出现ANV症状。ANV的心理和药物治疗的影响进行了讨论。
Investigated the prevalence of anticipatory nausea and vomiting (ANV) among 59 pediatric cancer patients who had routinely received ondansetron (Zofran®) antiemetic theraphy and determined patient–related factors associated with ANV. Of the sample, 59% indicated at least mild ANV symptoms, suggesting that a significant number of patients report ANV and are bothered by it, despite the use of Zofran. These children were compared to those reporting no ANV symptoms. Most ANV symptomatology was consistent with a traditional classical conditioning model although cognitive processes may also play a role. Children with greater expectations of severe postchemotherapy vomiting and those who were more distressed by nausea and vomiting were more likely to experience ANV symptoms. Implications for psychological and pharmacological treatments of ANV are discussed.