Developmental exposure to methylmercury alters learning and induces depression-like behavior in male mice
Developmental exposure to methylmercury alters learning and induces depression-like behavior in male mice
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DOI：
10.1093/toxsci/kfl199
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发表时间：
2007-06-01
影响因子：
3.8
通讯作者：
Ceccatelli, Sandra
中科院分区：
文献类型：
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作者：
Onishchenko, Natalia;Tamm, Christoffer;Ceccatelli, Sandra
为了研究发育暴露于甲基汞（MeHg）的长期影响，怀孕小鼠从妊娠第7天到分娩后第7天通过饮用水暴露于0.5 mg甲基汞/kglday。在515周龄和26-36周龄时，使用智能系统（IntelliCage）对雏鸡的行为进行监测，该系统用于连续长期记录社会群体的家笼行为，并对基本活动和学习进行复杂分析。此外，还研究了大鼠的自主运动、加速转盘上的运动协调、Morris水迷宫的空间学习和强迫游泳实验中的抑郁样行为。在没有社会剥夺的情况下进行的智力智力行为分析在检测活动和学习范式的变化方面更为敏感。我们发现mehg暴露的雄性小鼠运动功能正常，但探索活动减少，尤其是在年轻时。在接触甲基汞的雄性动物中观察到的学习障碍提示参考记忆障碍。有趣的是，强迫游泳测试揭示了暴露于甲基汞的雄性后代有抑郁样行为的倾向。本研究提供了新的证据，证明甲基汞的发育暴露不仅会影响认知功能，还会影响动机驱动行为。
To investigate the long-term effects of developmental exposure to methylmercury (MeHg), pregnant mice were exposed to at 0.5 mg MeHg/kglday via drinking water from gestational day 7 until day 7 after delivery. The behavior of offspring was monitored at 515 and 26-36 weeks of age using an automated system (IntelliCage) designed for continuous long-term recording of the home cage behavior in social groups and complex analysis of basic activities and learning. In addition, spontaneous locomotion, motor coordination on the accelerating rotarod, spatial learning in Morris water maze, and depression-like behavior in forced swimming test were also studied. The analysis of behavior performed in the IntelliCage without social deprivation occurred to be more sensitive in detecting alterations in activity and learning paradigms. We found normal motor function but decreased exploratory activity in MeHg-exposed male mice, especially at young age. Learning disturbances observed in MeHg-exposed male animals suggest reference memory impairment. Interestingly, the forced swimming test revealed a predisposition to depressive-like behavior in the MeHg-exposed male offspring. This study provides novel evidence that the developmental exposure to MeHg can affect not only cognitive functions but also motivation-driven behaviors.