Effects of human growth hormone administration on serum somatomedins, somatomedin carrier proteins, and growth rates in children with growth hormone deficiency.
Effects of human growth hormone administration on serum somatomedins, somatomedin carrier proteins, and growth rates in children with growth hormone deficiency.
复制标题
人生长激素给药对生长激素缺乏症儿童血清生长调节素、生长调节素载体蛋白和生长速度的影响。
DOI：
10.1210/jcem-55-1-49
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
M. J. Diehl
中科院分区：
文献类型：
--
作者：
D. Schalch;S. Tollefsen;G. Klingensmith;R. Gotlin;M. J. Diehl
本文对30例生长激素缺乏性身材矮小儿童在治疗前及治疗后3年的生长速度、血清生长调节素（Sm）和Sm载体蛋白（CP）水平进行了测定。最初，该组的平均（±SEM）骨龄（BA）（6.9 ± 0.5岁），（P<0.001）小于实际年龄（CA; 10.4 ± 0.7岁），及其增长率正常对照组CA（5.45 ± 0.22）cm/年，BA（6.46 ± 0.33）cm/年，CA（5.45 ± 0.22）cm/年，BA（6.46 ± 0.33）cm/年。与40名年龄匹配的对照组血清水平相比，我们发现总Sm胰岛素样生长因子（IGF）活性（0.31 ± 0.03 vs. 1.61 ± 0.12 μg/ml）、IGF-I（0.09 ± 0.02 vs. 0.44 ± 0.04 μ g/ml）和CP（123 ± 18.8 vs. 366 ± 28.2 μg/ml）浓度降低。总IGF和IGF-I均与生长迟缓程度呈负相关，表示为BA与CA的比值。21例受试者中，19例短期（18 h）给予GH（0.1 U/kg）后血清Sm升高，但升高幅度与对照组无显著性差异。
We have determined the growth rates and serum somatomedin (Sm) and Sm carrier protein (CP) levels in 30 children with GH deficiency and short stature before and up to 3 yr of GH therapy. Initially, the mean (±SEM) bone age (BA) of this group (6.9 ± 0.5 yr) was significantly (P<0.001) less than the chronological age (CA; 10.4 ± 0.7 yr), and their growth rate (3.45 ± 0.33 cm/yr) was markedly less than those of normal control groups matched either for CA (5.45 ± 0.22 cm/yr) or BA (6.46 ± 0.33 cm/yr). Compared to serum levels in a group of 40 age-matched controls, we found diminished concentrations of total Sm insulin-like growth factor (IGF) activity (0.31 ± 0.03 vs. 1.61 ± 0.12 μg/ml), IGF-I (0.09 ± 0.02 vs. 0.44 ± 0.04/ig/ml), and CP (123 ± 18.8 vs. 366 ± 28.2 μg/ml). Both total IGF and IGF-I were inversely related to the degree of growth retardation, expressed as the ratio of BA to CA. Serum Sm increased in 19 of 21 subjects after short term (up to 18 h) GH administration (0.1 U/kg), but the magnitude of ...
垂体功能减退症中的血浆生长调节素结合蛋白：生长激素治疗期间的变化。
DOI：
10.1210/jcem-53-1-100
发表时间：
1981
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Hintz,RL;Liu,F;Rosenfeld,RG;Kemp,SF
通讯作者：
Kemp,SF
对生长激素的急性生长调节素反应：放射受体测定与放射免疫测定。
DOI：
10.1210/jcem-52-4-616
发表时间：
1981
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Kemp,SF;Rosenfeld,RG;Liu,F;Gaspich,S;Hintz,RL
通讯作者：
Hintz,RL