Optical detection of the structural properties of tumor tissue generated by xenografting of drug-sensitive and drug-resistant cancer cells using partial wave spectroscopy (PWS).
Optical detection of the structural properties of tumor tissue generated by xenografting of drug-sensitive and drug-resistant cancer cells using partial wave spectroscopy (PWS).
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DOI：
10.1364/boe.10.006422
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发表时间：
2019-08
影响因子：
3.4
通讯作者：
P. Adhikari;P. K. Nagesh;Fatemah Alharthi;S. Chauhan;M. Jaggi;M. Yallapu;P. Pradhan
中科院分区：
文献类型：
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作者：
P. Adhikari;P. K. Nagesh;Fatemah Alharthi;S. Chauhan;M. Jaggi;M. Yallapu;P. Pradhan
基于介观物理的光学成像技术，部分波谱（PWS），已被用于通过探测细胞/组织中的纳米级结构变化来检测癌症。化疗期间耐药癌细胞/组织的发展是癌症治疗的主要挑战。在本文中，使用小鼠模型和PWS，研究了通过异种移植具有2D结构的耐药性和药物敏感性人类前列腺癌细胞以3D结构生长的肿瘤组织的结构特性。结果表明，3D异种移植组织保持与2D原始药物敏感和耐药细胞相似的结构紊乱特性程度等级。
A mesoscopic physics-based optical imaging technique, partial wave spectroscopy (PWS), has been used for the detection of cancer by probing nanoscale structural alterations in cells/tissue. The development of drug-resistant cancer cells/tissues during chemotherapy is a major challenge in cancer treatment. In this paper, using a mouse model and PWS, the structural properties of tumor tissue grown in 3D structures by xenografting drug-resistant and drug-sensitive human prostate cancer cells having 2D structures, are studied. The results show that the 3D xenografted tissues maintain a similar hierarchy of the degree of structural disorder properties as that of the 2D original drug-sensitive and drug-resistant cells.