Allostatic dysregulation of natural reward processing in prescription opioid misuse: autonomic and attentional evidence.
Allostatic dysregulation of natural reward processing in prescription opioid misuse: autonomic and attentional evidence.
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DOI：
10.1016/j.biopsycho.2015.01.005
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发表时间：
2015-02
影响因子：
2.6
通讯作者：
Howard, Matthew O.
中科院分区：
文献类型：
--
作者：
Garland, Eric L.;Froeliger, Brett;Howard, Matthew O.
滥用处方阿片类药物的慢性疼痛患者可能会出现自然奖励处理的非稳态失调。因此，本研究检查了患有慢性疼痛的处方阿片类药物滥用者（n = 72）相对于患有慢性疼痛的非滥用者（n = 26）是否表现出自然奖励反应性降低。受试者完成了一个点探针任务，包含疼痛相关，阿片类药物相关，和自然奖励刺激，同时注意力偏差（AB）的分数和心率变异性（HRV）的反应进行了评估。与非滥用者相比，滥用者在点探测任务中对阿片类药物、疼痛和自然奖励线索的HRV反应明显减弱。在注意自然奖励线索期间，HRV的这些显著组间差异最大，但在控制阿片类药物剂量的敏感性分析中变得不显著。此外，非滥用者证明了AB对自然奖励线索，而滥用者没有。研究结果表明，阿片类药物滥用者在奖励过程中表现出注意力和自主神经缺陷。
Chronic pain patients who misuse prescription opioids may suffer from allostatic dysregulation of natural reward processing. Hence, this study examined whether prescription opioid misusers with chronic pain (n = 72) evidenced decreased natural reward responsiveness relative to non-misusers with chronic pain (n = 26). Subjects completed a dot probe task containing pain-related, opioid-related, and natural reward stimuli while attentional bias (AB) scores and heart rate variability (HRV) responses were assessed. Compared to non-misusers, misusers evidenced significantly more attenuated HRV responses to opioid, pain, and natural reward cues presented during the dot probe task. These significant between-groups differences in HRV were largest during attention to natural reward cues, but became non-significant in a sensitivity analysis controlling for opioid dosing. In addition, non-misusers evidenced an AB toward natural reward cues, whereas misusers did not. Findings suggest that opioid misusers exhibit attentional and autonomic deficits during reward processing.
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DOI：
10.1016/j.jpain.2008.10.008
发表时间：
2009-02
期刊：
The journal of pain
影响因子：
--
作者：
Chou R;Fanciullo GJ;Fine PG;Adler JA;Ballantyne JC;Davies P;Donovan MI;Fishbain DA;Foley KM;Fudin J;Gilson AM;Kelter A;Mauskop A;O'Connor PG;Passik SD;Pasternak GW;Portenoy RK;Rich BA;Roberts RG;Todd KH;Miaskowski C;American Pain Society-American Academy of Pain Medicine Opioids Guidelines Panel
通讯作者：
American Pain Society-American Academy of Pain Medicine Opioids Guidelines Panel
影响因子：
7.4
作者：
Butler, Stephen F.;Budman, Simon H.;Jamison, Robert N.
通讯作者：
Jamison, Robert N.
影响因子：
17.7
作者：
Kalivas, PW;Volkow, ND
通讯作者：
Volkow, ND
影响因子：
3.4
作者：
Field, M;Mogg, K;Bradley, BP
通讯作者：
Bradley, BP
影响因子：
17.7
作者：
Heinz, A;Siessmeier, T;Bartenstein, P
通讯作者：
Bartenstein, P