Synthesis of boron-containing cholesterol derivatives for incorporation into unilamellar liposomes and evaluation as potential agents for BNCT
Synthesis of boron-containing cholesterol derivatives for incorporation into unilamellar liposomes and evaluation as potential agents for BNCT
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DOI：
10.1016/s0040-4020(99)00640-7
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发表时间：
1999-09-10
期刊：
影响因子：
2.1
通讯作者：
Harris, FR
中科院分区：
文献类型：
--
作者：
Feakes, DA;Spinler, JK;Harris, FR
制备了四种含碳硼烷的胆固醇衍生物，用于掺入单层脂质体的双层中，并评价其作为硼中子捕获治疗的潜在药物。所述衍生物使得能够评价连接基部分和碳硼烷头部基团的类型对双层稳定性和最终的体内肿瘤特异性的影响。(C)1999爱思唯尔科技有限公司。保留所有权利。
Four carborane-containing derivatives of cholesterol were prepared for incorporation into the bilayer of unilamellar liposomes and evaluation as potential agents for boron neutron capture therapy. The derivatives enable the evaluation of the linker moiety and the type of carborane head group on the bilayer stability and ultimate in vivo tumor specificity. (C) 1999 Elsevier Science Ltd. All rights reserved.