Clinical evaluation of circulating serum sialyl Tn antigen levels in patients with epithelial ovarian cancer.
Clinical evaluation of circulating serum sialyl Tn antigen levels in patients with epithelial ovarian cancer.
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上皮性卵巢癌患者循环血清唾液酸 Tn 抗原水平的临床评价。
DOI：
10.1200/jco.1991.9.6.983
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
Y. Kawashima
中科院分区：
文献类型：
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作者：
H. Kobayashi;T. Terao;Y. Kawashima
已确定在粘蛋白型糖链的核心结构中具有抗原特异性的唾液酸Tn抗原（NeuAc α 2-6GalNac α 1-在本研究中，我们评估了这种新的碳水化合物抗原在上皮性卵巢癌患者中的临床意义。使用放射免疫测定法检测血清中的抗人CD 4抗原，在50.0%的卵巢癌患者中观察到抗原水平升高（大于或等于32.6 U/mL）。相比之下，3.8%的健康个体的ESTA抗原水平大于或等于32.6 U/mL。在9.6%的良性妇科疾病患者和0%的孕妇中，有升高的抗原水平。卵巢癌患者与良性妇科疾病患者、孕妇或对照组之间的CEA抗原水平存在显著差异（P <0.001）。所有评价的卵巢癌样本的平均值+/- SD为109.2 +/- 146.8 U/mL。平均值和阳性率均随分期的进展而增加。按组织学类型分，粘液腺癌阳性率最高（61.0%）。用ELISA法检测卵巢癌患者血清中CEA的敏感性为50.0%，特异性为93.5%，阳性预测值为72.2%，阴性预测值为84.7%，诊断价值为46.8%。33例血清CA 125抗原水平低于35 U/mL的卵巢癌患者中有12例血清CA 125抗原水平升高。虽然CA 125抗原水平在74.6%的同一人群中升高，而CA 125抗原水平在50.0%的同一人群中升高，但使用这两种检测试剂盒表明，在所研究的人群中检测灵敏度为83.8%。
Sialyl Tn antigen (NeuAc alpha 2----6GalNac alpha 1----0-Ser/Thr [STN]) with antigenic specificity in the core structure of mucin-type carbohydrate chains has been determined. In the present study, we evaluated the clinical significance of this new carbohydrate antigen, STN, in patients with epithelial ovarian cancer. With the use of a radioimmunoassay developed to detect STN antigen in serum, elevated (greater than or equal to 32.6 U/mL) antigen levels were observed in 50.0% of patients with ovarian cancer. In contrast, 3.8% of healthy individuals had STN antigen levels greater than or equal to 32.6 U/mL. In 9.6% of patients with benign gynecologic diseases and 0% of pregnant women, there were elevated levels of STN antigen. There was a significant difference (P less than .001) in STN antigen levels between patients with ovarian cancer and patients with benign gynecologic diseases, pregnant women, or the controls. The mean +/- SD for all evaluated samples of ovarian cancer was 109.2 +/- 146.8 U/mL. Both the mean values and the positive rate increased as the stage advanced. Classified according to the histologic type, the highest positive rate (61.0%) was observed in mucinous adenocarcinoma. The usefulness of STN antigen as a circulating tumor marker in ovarian cancer was estimated as follows: sensitivity 50.0%, specificity 93.5%, positive predictive value 72.2%, negative predictive value 84.7%, and diagnostic value 46.8%. Serum STN antigen levels were elevated in 12 of 33 patients with ovarian cancer who had serum CA 125 antigen levels less than 35 U/mL. While CA 125 antigen levels were elevated in 74.6% and STN antigen levels were elevated in 50.0% of the same population, the use of both assays indicated the sensitivity of detection of 83.8% in the population studied.
T 和 Tn 抗原在乳腺癌最早组织学阶段和整个过程中的基本和诊断作用。
DOI：
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发表时间：
1986
期刊：
Progress in clinical and biological research
影响因子：
--
作者：
Springer,GF;Desai,PR;Robinson,MK;Tegtmeyer,H;Scanlon,EF
通讯作者：
Scanlon,EF