Significant association between DRD3 gene body methylation and schizophrenia
Significant association between DRD3 gene body methylation and schizophrenia
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DRD3基因体甲基化与精神分裂症之间的显着相关性
DOI：
10.1016/j.psychres.2014.08.032
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发表时间：
2014-12-30
影响因子：
11.3
通讯作者：
Duan, Shiwei
中科院分区：
文献类型：
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作者：
Dai, Dongjun;Cheng, Jia;Duan, Shiwei
目前的研究是第一个揭示DRD3甲基化对不同（SCZ）亚型风险的贡献。本研究共包括30名偏执狂（15名男性和15名女性）和29名未分化（15名男性和14名女性）SCZ患者和26名年龄和性别匹配的对照组。我们的研究结果表明，CpG 2与SCZ的显着关联。按性别分类的分析显示，男性患者的CpG2和CpG3甲基化显著高于男性对照，女性患者的CpG5甲基化显著高于女性对照。性别和SCZ亚型的进一步细分分析显示，男性偏执型SCZ和男性未分化SCZ中CpG2和CpG3甲基化显著高于男性对照。相反，女性未分化SCZ中CpG2和CpG3甲基化显著低于女性对照。此外，女性偏执型SCZ中CpG5甲基化显著高于女性对照。总之，我们的研究结果支持DRD3基因体高甲基化与SCZ的风险显著相关。未来的研究需要阐明DRD3基因体高甲基化导致SCZ风险的机制。(C)2014爱思唯尔爱尔兰有限公司版权所有。
The current study was the first one to reveal the contribution of DRD3 methylation to the risk of different (SCZ) subtypes. This study comprised a total of 30 paranoid (15 males and 15 females) and 29 undifferentiated (15 males and 14 females) SCZ patients and 26 age- and gender-matched controls. Our results showed a significant association of CpG2 with SCZ. A breakdown analysis by gender showed that CpG2 and CpG3 methylation were significantly higher in male patients than male controls, and that CpG5 methylation was significantly higher in female patients than female controls. A further breakdown analysis by both gender and SCZ subtype showed that CpG2 and CpG3 methylation were significantly higher in male paranoid SCZ and male undifferentiated SCZ than male controls. In contrast, CpG2 and CpG3 methylation were significantly lower in female undifferentiated SCZ than female controls. Additionally, CpG5 methylation was significantly higher in female paranoid SCZ than female controls. In conclusion, our findings supported that DRD3 gene body hypermethylation was significantly associated with the risk of SCZ. Future study is needed to clarify the mechanisms by which DRD3 gene body hypermethylation contributes to the risk of SCZ. (C) 2014 Elsevier Ireland Ltd. All rights reserved.