Phosphorylation of cAMP response element-binding protein, CRE-BP1, by cAMP-dependent protein kinase and protein kinase C.
Phosphorylation of cAMP response element-binding protein, CRE-BP1, by cAMP-dependent protein kinase and protein kinase C.
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cAMP 依赖性蛋白激酶和蛋白激酶 C 磷酸化 cAMP 反应元件结合蛋白 CRE-BP1。
DOI：
10.1016/0006-291x(91)91237-7
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发表时间：
1991
影响因子：
3.1
通讯作者：
A. Kishimoto
中科院分区：
文献类型：
--
作者：
A. Sakurai;T. Maekawa;T. Sudo;S. Ishii;A. Kishimoto
在体外，人重组CRE-BP 1被cAMP依赖性蛋白激酶和蛋白激酶C磷酸化。这两种蛋白激酶修饰CRE-BP 1的不同丝氨酸残基。CRE-BP 1的金属指结构下游的Ser-62是cAMP依赖性蛋白激酶的磷酸化位点，而位于该蛋白碱性区域的两个丝氨酸残基Ser-340和Ser-367是主要的蛋白激酶C磷酸化位点。CRE-BP 1的转录和DNA结合活性可能受这些蛋白激酶磷酸化的调节。
The human recombinant CRE-BP1 was phosphorylated by cAMP-dependent protein kinase and protein kinase C,in vitro. These two protein kinases modified distinct serine residues of CRE-BP1. Ser-62 downstream of a putative metal finger structure of CRE-BP1 was the phosphorylation site by cAMP-dependent protein kinase, whereas two serine residues, Ser-340 and Ser-367, located in the basic region of this protein were the major protein kinase C phosphorylation sites. It seems possible that transcriptional and DNA-binding activaties of CRE-BP1 are regulated by phosphorylation with these protein kinases.
影响因子：
56.9
作者：
HOEFFLER, JP;MEYER, TE;HABENER, JF
通讯作者：
HABENER, JF
平滑肌肌球蛋白轻链中被蛋白激酶 C 磷酸化的位点序列。
DOI：
--
发表时间：
1987
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Bengur,AR;Robinson,EA;Appella,E;Sellers,JR
通讯作者：
Sellers,JR
影响因子：
56.9
作者：
SHENG, M;THOMPSON, MA;GREENBERG, ME
通讯作者：
GREENBERG, ME