Biomechanical properties of the proximal femur determined in vitro by single-energy quantitative computed tomography.
Biomechanical properties of the proximal femur determined in vitro by single-energy quantitative computed tomography.
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通过单能定量计算机断层扫描体外测定股骨近端的生物力学特性。
DOI：
10.1002/jbmr.5650040510
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Hayes,WC
中科院分区：
文献类型：
--
作者：
Esses,SI;Lotz,JC;Hayes,WC
为了评估定量计算机断层扫描作为骨质疏松性髋关节骨折的体内预测指标的使用，我们检查了单能量定量计算机断层扫描数据与股骨近端小梁骨力学特性之间的体外关系，校正了扫描仪漂移。测量了49个样品的表观密度和极限强度，并确定了它们与计算机断层扫描数据的函数关系。表观密度与计算机断层扫描次数呈中等线性相关（R2= 0.60），最终强度呈幂律相关（R2= 0.83）。此外，对于8个完整的股骨，在受控的体外条件下，亚股骨头区的平均计算机断层扫描数据与最终骨折负荷有一定的相关性（R2= 0.64）。这些股骨的平均断裂能为43焦，比从站立高度坠落的能量低一个数量级以上，这表明坠落力学是骨折风险的重要决定因素，比之前认为的要重要。吸收到失效的能量与计算机断层扫描数据之间的关系最好用幂律来描述（R2= 0.90）。基于这些结果，定量计算机断层扫描似乎为直接估计骨折风险的组成部分提供了一种潜在的有用方法，可以归因于骨强度的降低。
To assess the use of quantitative computed tomography as an in vivo predictor of fracture in the osteoporotic hip, we examined the in vitro relationship between single‐energy quantitative computed tomography data, calibrated for scanner drift, and the mechanical properties of trabecular bone from the proximal femur. For 49 samples, the apparent density and ultimate strength were measured and their functional relationship to the computed tomography data determined. Apparent density demonstrated a moderate linear correlation to the computed tomography numbers (R2= 0.60), and the ultimate strength was related through a power law (R2= 0.83). In addition, for 8 intact femora, average computed tomographic data from the sub‐capital region were moderately correlated to the ultimate fracture load applied under controlled in vitro conditions (R2= 0.64). The average fracture energy for these femora was 43 J, a value more than an order of magnitude less than the energy available in a fall from standing height, suggesting that fall mechanics are a more important determinant of fracture risk than has been previously thought. The relationship between the energy absorbed to failure and the computed tomography data was best described by a power law (R2= 0.90). Based on these results, it appears that quantitative computed tomography provides a potentially useful approach for the direct estimate of that component of fracture risk that can be attributed to a reduction in bone strength.