BAFF enhances B-cell-mediated immune response and vaccine-protection against a very virulent IBDV in chickens
BAFF enhances B-cell-mediated immune response and vaccine-protection against a very virulent IBDV in chickens
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BAFF 增强 B 细胞介导的免疫反应和疫苗保护，抵抗鸡中毒性极强的 IBDV
DOI：
10.1016/j.vaccine.2008.12.040
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发表时间：
2009-02-25
期刊：
影响因子：
5.5
通讯作者：
Zhang, Shuang Quan
中科院分区：
文献类型：
--
作者：
Chen, Long;Ran, Mao Ju;Zhang, Shuang Quan
传染性法氏囊病（Infectious bursal disease，IBD）是由传染性法氏囊病毒（IBDV）引起的一种急性、高度传染性和免疫抑制性疾病，其特异性靶向破坏法氏囊中的B细胞。属于TNF家族的B细胞活化因子（BAFF，也称为BLyS、TALL-1、THANK或zTNF 4）是B细胞增殖和存活的重要因子。本研究证明，人可溶性BAFF（hsBAFF）可通过提高免疫鸡的B淋巴细胞分泌免疫球蛋白（IG）如伊加、IgM和IgG的活性，增强其体液免疫应答。重要的是，我们发现hsBAFF作为疫苗接种的共免疫刺激剂，可以在放大特异性保护性免疫应答中发挥至关重要的作用，从而有效地防止超强力IBDV攻击。血清学证据表明，hsBAFF能有效地提高免疫鸡血清中特异性IgG的活性和滴度，提示BAFF可与特异性疫苗联用预防IBD。(C)2009爱思唯尔有限公司保留所有权利。
Infectious bursal disease (IBD) is an acute, highly infectious and immunosuppressive disease caused by IBDV, which specifically targets destruction of B cells in the bursa of Fabricius. B-cell activating factor belonging to the TNF family (BAFF, also called BLyS, TALL-1, THANK, or zTNF4) is an important factor for B-cell proliferation and survival. Here we demonstrate that human soluble BAFF (hsBAFF) may enhance humoral immune response by elevating B lymphocyte activity of secretion Of immunoglobulin (Ig) Such as IgA, IgM and IgG in chickens immunized or unimmunized with an inactivated IBDV vaccine from a very virulent strain. Of importance, we found that hsBAFF, as a co-immunostimulant for vaccination, may play a vital role in amplifying the specific protective immune response, thereby potently preventing very virulent IBDV challenge. This is supported by serological evidence that hsBAFF may effectively enhance higher specific IgG activity and titre in serum of immunized chickens,The findings strongly suggest that BAFF may be exploited in combination with specific vaccination for prevention of IBD. (C) 2009 Elsevier Ltd. All rights reserved.