Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta‐catenin signaling pathway
Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta‐catenin signaling pathway
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DOI：
10.1016/j.febslet.2015.04.011
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发表时间：
2015-05
期刊：
影响因子：
3.5
通讯作者：
Yu-mei Zhang;Yuan-yuan Zhang;A. Bulbul;Xiu Shan;Xiao-Qi Wang;Q. Yan
中科院分区：
文献类型：
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作者：
Yu-mei Zhang;Yuan-yuan Zhang;A. Bulbul;Xiu Shan;Xiao-Qi Wang;Q. Yan
糖基化在决定子宫内膜对胚胎的接受性中起重要作用。岩藻糖基转移酶IV（FUT 4）在子宫内膜中表达，并被认为是子宫内膜容受性的标志物。黄芩苷是黄酮类化合物的单体，具有促进生殖的作用。然而，黄芩苷调节胚胎-子宫内膜粘附中FUT 4表达的机制仍不清楚。结果表明，黄芩苷能显著提高人子宫内膜细胞和小鼠子宫内膜组织中FUT 4 mRNA和蛋白的表达水平，并能持续提高小鼠胚胎体外着床过程中的粘附率和胚胎着床能力。本研究提示黄芩苷通过Wnt/β-catenin信号通路上调FUT 4表达，促进子宫内膜增殖。
Glycosylation plays a significant role in determining the receptivity of the uterine endometrium to embryo. Fucosyltransferase IV (FUT4) is expressed stage-specifically in the uterine endometrium of mammalians, and considered as a marker of the endometrial receptivity. Baicalin, a monomer of flavonoids, is known to have functions in improving reproduction. However, the mechanism by which baicalin regulates the expression of FUT4 in embryo-endometrium adhesion remains unclear. Our results showed that baicalin significantly increased FUT4 mRNA and protein expression levels both in human endometrial cells and mouse endometrial tissue, and consistently elevated embryo adhesion rate during implantation in vitro and embryonic implantation competence in pregnant mouse. This study suggests that baicalin facilitates endometrial reproduction via elevating FUT4 expression through Wnt/β-catenin signaling pathway.