Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice.
Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice.
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DOI：
10.1002/hep.23431
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发表时间：
2010-04
期刊：
影响因子：
13.5
通讯作者：
Huppert, Stacey S.
中科院分区：
文献类型：
--
作者：
Sparks, Erin E.;Huppert, Kari A.;Brown, Melanie A.;Washington, M. Kay;Huppert, Stacey S.
Alagille syndrome, a chronic hepatobiliary disease, is characterized by paucity of intrahepatic bile ducts (IHBDs). To determine the impact of Notch signaling specifically on IHBD arborization we studied the influence of both chronic gain and loss of Notch function on the intact three-dimensional IHBD structure using a series of mutant mouse models and a resin casting method. Impaired Notch signaling in bi-potential hepatoblast progenitor cells (BHPCs) dose-dependently decreased the density of peripheral IHBDs, whereas activation of Notch1 results in an increased density of peripheral IHBDs. While Notch2 has a dominant role in IHBD formation there is also a redundant role for other Notch receptors in determining the density of peripheral IHBDs. Since changes in IHBD density do not appear to be due to changes in cellular proliferation of bile duct progenitors, we suggest that Notch plays a permissive role in cooperation with other factors to influence lineage decisions of BHPCs and sustain peripheral IHBDs. There is a threshold requirement for Notch signaling at multiple steps, IHBD tubulogenesis and maintenance, during hepatic development that determines the density of three-dimensional peripheral IHBD architecture.
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影响因子：
30.8
作者：
Li, LH;Krantz, ID;Spinner, NB
通讯作者：
Spinner, NB
影响因子：
13.5
作者：
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通讯作者：
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影响因子：
4
作者：
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通讯作者：
Miyajima, A
影响因子：
4.4
作者：
Han, H;Tanigaki, K;Honjo, T
通讯作者：
Honjo, T
影响因子：
3.3
作者：
Tanimizu, Naoki;Miyajima, Atsushi;Mostov, Keith E.
通讯作者：
Mostov, Keith E.