Improving mass spectrometer sensitivity using a high-pressure electrodynamic ion funnel interface
Improving mass spectrometer sensitivity using a high-pressure electrodynamic ion funnel interface
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DOI：
10.1016/j.jasms.2006.06.005
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发表时间：
2006-09-01
影响因子：
3.2
通讯作者：
Smith, Richard D.
中科院分区：
文献类型：
--
作者：
Ibrahim, Yehia;Tang, Keqi;Smith, Richard D.
我们报告了一种新的电动离子漏斗，在30托的压力下工作，没有离子传输损失。通过降低离子漏斗电容，提高射频驱动频率（1.7 MHz）和振幅（100-170 V），与先前在< 5 torr压力下优化的离子漏斗设计相比，性能得到了增强。在2 ~ 30托的压力下，离子传输没有退化。能够在更高的压力下工作，使得新的串联离子漏斗质谱仪接口设计能够适应更大的气体负荷（例如，来自ESI源）。当与多毛细管入口结合使用时，该界面提供了更有效的离子引入，从而显著提高了质谱仪的灵敏度和检测限。（J Am Soc质谱，2006,17,1299-1305）(c) 2006美国质谱学会。
We report on a new electrodynamic ion funnel that operates at a pressure of 30 torr with no loss of ion transmission. The enhanced performance compared with previous ion funnel designs optimized for pressures of < 5 torr was achieved by reducing the ion funnel capacitance and increasing the RF drive frequency (1.7 MHz) and amplitude (100-170 V peak-to-peak). No degradation of ion transmission was observed for pressures from 2 to 30 torr. The ability to operate at higher pressure enabled a new tandem ion funnel mass spectrometer interface design that can accommodate a greater gas load (e.g., from an ESI source). When combined with a multicapillary inlet, the interface provided more efficient introduction of ions, resulting in a significant enhancement in mass spectrometer sensitivity and detection limits. (J Am Soc Mass Spectrom 2006, 17, 1299-1305) (c) 2006 American Society for Mass Spectrometry.