Molecular Analyses of Aspirated Cystic Fluid for the Differential Diagnosis of Cystic Lesions of the Pancreas: A Systematic Review and Meta-Analysis.
Molecular Analyses of Aspirated Cystic Fluid for the Differential Diagnosis of Cystic Lesions of the Pancreas: A Systematic Review and Meta-Analysis.
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抽吸囊性液体的分子分析用于胰腺囊性病变的鉴别诊断：系统评价和荟萃分析
DOI：
10.1155/2016/3546085
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发表时间：
2016
影响因子：
2
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
Guo X;Zhan X;Li Z
背景研究人员已经评估了各种分子测试，以提高胰腺囊性病变的鉴别诊断。方法.在6个电子数据库中检索关于胰腺囊肿诊断的分子检测的文章。从选定的文章中提取准确性指标，并通过随机效应模型进行汇总。总结受试者工作特征曲线用于分析分子检测的总体准确度。报告了合并的灵敏度和特异性值[95%置信区间]。结果该系统性综述包括8项研究，共428例患者。我们确定了KRAS突变检测的敏感性和特异性，（0.47 [0.39-0.54]，0.98 [0.93-0.99]）和杂合性丢失（0.63 [0.54-0.71]，0.76 [0.63-0.87]）用于区分粘液性囊肿和非粘液性囊肿，以及KRAS突变检测的敏感性和特异性（0.59 [0.46-0.71]，0.78 [0.71-0.85]）和杂合性缺失（0.89 [0.78-0.96]，0.69 [0.60-0.76]）。结论KRAS突变的测试可以确认但不排除粘液性或恶性胰腺囊肿的诊断。
Background. Researchers have evaluated various molecular tests for improving the differential diagnosis of cystic lesions of the pancreas. Methods. Six electronic databases were searched for articles on molecular tests for the diagnosis of pancreatic cysts. Measures of accuracy were extracted from selected articles and pooled by the random-effects model. Summary receiver operating characteristic curves were used to analyze the overall accuracy of the molecular tests. Pooled sensitivity and specificity values [95% confidence intervals] are reported. Results. The systematic review included eight studies of 428 patients in total. We determined the sensitivities and specificities of tests for KRAS mutations (0.47 [0.39–0.54], 0.98 [0.93–0.99]) and loss of heterozygosity (0.63 [0.54–0.71], 0.76 [0.63–0.87]) for distinguishing mucinous from nonmucinous cysts, as well as the sensitivities and specificities of tests for KRAS mutations (0.59 [0.46–0.71], 0.78 [0.71–0.85]) and loss of heterozygosity (0.89 [0.78–0.96], 0.69 [0.60–0.76]) for differentiating malignant from benign cysts. Conclusion. Tests of KRAS mutations could confirm but not exclude a diagnosis of a mucinous or malignant pancreatic cyst.