On track with P-bodies
On track with P-bodies
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DOI：
10.1042/bst0380242
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发表时间：
2010-02-01
影响因子：
3.9
通讯作者：
Stoecklin, Georg
中科院分区：
文献类型：
--
作者：
Kulkarni, Meeta;Ozgur, Sevim;Stoecklin, Georg
p体（加工体）是光镜下在脊椎动物和无脊椎动物体细胞以及酵母、植物和锥虫中可见的细胞质灶。在分子水平上，p -小体是特定Trill和蛋白质的动态聚集体，具有双重功能：首先，它们含有翻译沉默的mRNA，这些mRNA可以再次从p -小体中退出，重新参与翻译。其次，p小体通过decapping/Xrn1途径招募靶向死基化和降解的mrna。虽然某些蛋白质是p小体的核心成分，但其他参与识别短寿命mRNA的蛋白质只有在mRNA衰减减弱时才能被困在p小体中。这反映了许多蛋白质与p体的短暂相互作用。本文综述了近年来在p体功能、组装和运动方面的研究进展。一份定位于p体的蛋白质和rna的最新清单将有助于跟踪这一快速发展的领域。
P-bodies (processing bodies) are cytoplasmic foci visible by light microscopy in somatic cells of vertebrate and invertebrate origin as well as in yeast, plants and trypanosomes. At the molecular level, P-bodies are dynamic aggregates of specific Trill and proteins that serve a dual function: first, they harbour mRNAs that are translationally silenced, and such mRNA can exit again from P-bodies to re-engage in translation. Secondly, P-bodies recruit mRNAs that are targeted for deadenylation and degradation by the decapping/Xrn1 pathway. whereas certain proteins are core constituents of P-bodies, others involved in recognizing short-lived mRNAs can only be trapped in P-bodies when mRNA decay is attenuated. This reflects the very transient interactions by which many proteins associate with P-bodies. In the present review, we summarize recent findings on the function, assembly and motility of P-bodies. An updated list of proteins and RNAs that localize to P-bodies will help in keeping track of this fast-growing field.