Plasma amino acid concentrations in children receiving long-term parenteral nutrition.
Plasma amino acid concentrations in children receiving long-term parenteral nutrition.
复制标题
接受长期肠外营养的儿童的血浆氨基酸浓度。
DOI：
10.1097/00005176-198809000-00021
复制
发表时间：
1988
影响因子：
2.9
通讯作者：
Kopple,JD
中科院分区：
文献类型：
--
作者：
Dahlström,KA;Ament,ME;Laidlaw,SA;Kopple,JD
测定了15名接受家庭肠外营养（PN）的4-65个月儿童和10名正常对照者的血浆氨基酸浓度。7例患者（I组）。PN是唯一的营养来源。8例患者（II组）摄取其总能量需求的30%-70%，其余的通过静脉注射。I组和II组患者的PN治疗时间分别为25.6 × 14.4 （SD）和25.7 × 19.1个月。与对照组相比。1组总必需氨基酸、三支链氨基酸的血浆浓度显著降低。胱氨酸，酪氨酸和三种主要的尿素循环氨基酸。II组患儿表现出两支链氨基酸的血浆浓度降低。亮氨酸和缬氨酸，还有胱氨酸和酪氨酸。两组的牛磺酸水平均有所下降。肝脏疾病的存在对氨基酸水平没有重大影响。这些数据表明，长期接受肠外营养的儿童，即使在静脉注射中摄入了足量的氨基酸，其血浆氨基酸浓度也会出现异常。需要进一步的研究来评估改变静脉注射氨基酸是否会使这些儿童的血浆氨基酸浓度正常化。
Plasma amino acid concentrations were measured in 15 children aged 4–65 months who received home parenteral nutrition (PN) and in 10 normal controls. In seven patients (Group I). PN was the only source of nutrition. Eight patients (Group II) ingested 30%–70% of their total energy requirements and received the remainder intravenously. Group I and Group II patients received PN for 25.6 × 14.4 (SD) and 25.7 × 19.1 months, respectively. In comparison to controls. Group I had significantly decreased plasma concentrations of total essential amino acids, the three branched chain amino acids. cystine, tyrosine, and the three major urea cycle amino acids. Group II children displayed decreased plasma concentrations of two branched chain amino acids. leucine and valine, as well as cystine and tyrosine. Taurine was decreased in both groups. The presence of liver disease did not have a major effect on amino acid levels. These data indicate that children receiving long‐term parenteral nutrition will develop abnormalities in their plasma amino acid concentrations even though they appear to receive adequate amounts of amino acids in their intravenous solutions. Further studies will be necessary to assess whether modifying the intravenous intake of amino acids will normalize plasma amino acid concentrations in these children.