P53 promoter selection - Choosing between life and death
P53 promoter selection - Choosing between life and death
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DOI：
10.4161/cc.7.2.5236
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发表时间：
2008-01-15
期刊：
影响因子：
4.3
通讯作者：
Lee, Sam W.
中科院分区：
文献类型：
--
作者：
Das, Sanjeev;Boswell, Sarah A.;Lee, Sam W.
关于遗传毒性应激反应的一个关键的未解决的问题是p53肿瘤抑制因子的激活如何导致细胞周期停滞和DNA修复或凋亡。p53是细胞中最重要的肿瘤抑制蛋白之一，可阻止受损DNA的遗传转移。在不同的胁迫条件下，p53迅速积累并作为序列特异性DNA结合转录因子调节大量靶基因。p53的激活有两个主要结果：细胞周期停滞或凋亡。在这篇综述中，我们试图列举影响p53启动子选择的不同修饰和辅助因子，并展示p53如何选择细胞的生命或死亡。
A crucial unresolved issue about the genotoxic stress response is how the activation of the p53 tumor suppressor can lead either to cell cycle arrest and DNA repair or to apoptosis. p53 is one of the most important tumor suppressor proteins in the cell to prevent to heritable transfer of damaged DNA. In response to different stress conditions p53 rapidly accumulates and functions as a sequence specific DNA-binding transcription factor to regulate a large number of target genes. Activation of p53 has two major outcomes: cell cycle arrest or apoptosis. In this review we attempt to enumerate the different modifications and co-factors that influence p53 promoter selection and demonstrate how p53 chooses life or death for the cell.