Human Lymphocyte Antigen DR Types in Relation to Early Clinical Manifestations in Diabetic Children
Human Lymphocyte Antigen DR Types in Relation to Early Clinical Manifestations in Diabetic Children
复制标题
人类淋巴细胞抗原 DR 类型与糖尿病儿童早期临床表现的关系
DOI：
10.1203/00006450-198412000-00002
复制
发表时间：
1984
影响因子：
3.6
通讯作者：
B. Lindblom
中科院分区：
文献类型：
--
作者：
J. Ludvigsson;B. Lindblom
摘要：对117例发病年龄在0.5 ~ 17岁（平均值± SD，9.0 ± 3.9）的胰岛素依赖型糖尿病患者进行了人类淋巴细胞抗原（HLA）DR分型，其中115例为DR 3和/或DR 4阳性。DR 4非常常见，在82.9%的患者中单独或与其他DR类型合并出现。只有两个孩子是DR 2阳性，但他们也是DR 4阳性。DR 3和DR 4患者之间的比较显示，DR 4患者表现出发病的季节性变化（最常见的发病在春季和秋季），在发病时有更严重的疾病体征和症状，并且不太可能比DR 3患者部分缓解。结果支持胰岛素依赖型糖尿病是一种遗传异质性疾病的假设。
ABSTRACT: Human lymphocyte antigen (HLA)-DR-typing was performed in 117 insulin-dependent diabetics with age at onset between 0.5 and 17 years (mean ± SD, 9.0 ± 3.9); 115 of 117 patients were DR3- and/or DR4-posirive. DR4 was very common, seen alone or in combination with other DR types in 82.9% of the patients. Only two children were DR2-positive, but they also were DR4-positive. A comparison between DR3 and DR4 patients snowed that DR4 patients manifested a seasonal variation of onset (most common onset during spring and autumn), had more severe signs and symptoms of the disease at onset, and were less likely to have a partial remission than patients with DR3. The results support the hypothesis that insulindependent diabetes mellitus is a genetically heterogeneous disease.