Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression.
Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression.
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DOI：
10.1016/j.jcf.2008.09.006
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发表时间：
2009-01
影响因子：
5.2
通讯作者：
Miller, Samuel I.
中科院分区：
文献类型：
--
作者：
Hoffman, Lucas R.;Kulasekara, Hemantha D.;Emerson, Julia;Houston, Laura S.;Burns, Jane L.;Ramsey, Bonnie W.;Miller, Samuel I.
铜绿假单胞菌与突变的转录调节因子LasR慢性感染的人与囊性纤维化（CF）的气道，但患病率和临床意义的LasR突变感染是未知的。在一项探索性研究中，我们筛选了来自58例CF患者的166株铜绿假单胞菌分离株的LasR失活和粘液性，并比较了来源患者的临床特征。lasR突变的发生率与最佳描述的CF适应性表型粘液性的发生率相当，但受影响的患者平均年轻约2岁。在回归分析中，lasR突变体感染患者的肺功能随年龄的下降比未感染患者更严重，与粘液性的影响相似。lasR突变铜绿假单胞菌的培养阳性可作为具有预后意义的早期CF适应性变化的标志物。此外，由于LasR失活改变了对抗生素的敏感性，因此感染lasR突变型铜绿假单胞菌可能会影响对治疗的反应。
Pseudomonas aeruginosa with mutations in the transcriptional regulator LasR chronically infect the airways of people with cystic fibrosis (CF), yet the prevalence and clinical implications of lasR mutant infection are unknown. In an exploratory study, we screened 166 P. aeruginosa isolates from 58 CF patients for LasR inactivation and mucoidy, and compared clinical characteristics among source patients. lasR mutation prevalence was comparable to that of mucoidy, the best-described CF-adapted phenotype, but affected patients were on average approximately 2 years younger. In a regression analysis, lung function decline with age was worse among patients with lasR mutant infection than in those without, similar to the effect of mucoidy. Culture positivity for lasR mutant P. aeruginosa may serve as a marker of early CF adaptive change of prognostic significance. Furthermore, as LasR inactivation alters susceptibility to antibiotics, infection with lasR mutant P. aeruginosa may impact response to therapy.
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