Oral tolerance and gut-oriented immune response to dietary proteins.
Oral tolerance and gut-oriented immune response to dietary proteins.
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DOI：
10.1007/s11882-001-0067-6
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发表时间：
2001-11-01
影响因子：
5.5
通讯作者：
Alpan, O
中科院分区：
文献类型：
--
作者：
Alpan, O
膳食蛋白质可诱导以产生IgA为特征的局部免疫反应和以产生TH2/TH3细胞因子为特征的全身免疫反应。通过影响免疫反应的类别，肠道增强了免疫系统对抗通过饮食进入体内的蛋白质的功效，同时确保了自身的安全。本文回顾和总结了“口腔耐受”领域，重点介绍了最近的进展。
Dietary proteins induce both a local immune response characterized by IgA production and systemic immune response characterized by the production of TH2/TH3 cytokines. By influencing the class of immune response, the gut enhances the efficacy of immunity against proteins that enter the body through the diet while, at the same time, ensuring its own safety. This article reviews and summarizes the field of "oral tolerance," with emphasis on recent advancements.