Perspectives on: SGP symposium on mitochondrial physiology and medicine: molecular identities of mitochondrial Ca2+ influx mechanism: updated passwords for accessing mitochondrial Ca2+-linked health and disease.
Perspectives on: SGP symposium on mitochondrial physiology and medicine: molecular identities of mitochondrial Ca2+ influx mechanism: updated passwords for accessing mitochondrial Ca2+-linked health and disease.
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DOI：
10.1085/jgp.201210795
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发表时间：
2012-06
期刊：
影响因子：
--
通讯作者：
Sheu SS
中科院分区：
文献类型：
--
作者：
O-Uchi J;Pan S;Sheu SS
BackgroundMitochondria were originally found and studied simply as a cellular power-plant in the first half of the 20th century (Drago et al., 2011). Soon it was also recognized that Ca 2+ stimulates the Krebs cycle and electron transport chain activity, which results in the stimulation of ATP synthesis (Balaban, 2009; Denton, 2009; Carafoli, 2010). Early studies in the 1960s to 1970s revealed that isolated mitochondria could take up a large quantity of Ca 2+(Deluca et al., 1962; Vasington and Murphy, 1962). Surprisingly, super-physiological high Ca 2+ concentrations ([Ca 2+])(10–100 µM) were required to activate Ca 2+ uptake into isolated mitochondria. However, in the intact cells, less than a 10-µM [Ca 2+] increase in the cytosol by receptor stimulation indeed propagated into mitochondria matrix (Rizzuto et al., 1992; Jou et al., 1996). This discrepancy between isolated mitochondria and intact cells was partially resolved by the finding of high cytosolic [Ca 2+]([Ca 2+] c) at microdomains between mitochondria and ER/SR, which possesses Ca 2+-releasing channels, inositol 1, 4, 5-trisphosphate (IP 3) receptor, and/or RyR because of their physical proximity (Rizzuto et al., 1998, 2009; Sharma et al., 2000; Csordás et al., 2010; Giacomello et al., 2010)(Figs. 1 and 3). The functional tight coupling between ER/SR and mitochondria is attributed to the inter-organelle tether proteins such as mitofusin 2 (de Brito and Scorrano, 2008; García-Pérez et al., 2011)(Fig. 1). These seminal discoveries have positioned mitochondria as one of the key players in the dynamic regulation of physiological Ca 2+ signaling.
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DOI：
10.1074/jbc.m110.216044
发表时间：
2011-09-16
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
De Marchi U;Castelbou C;Demaurex N
通讯作者：
Demaurex N
DOI：
10.1073/pnas.012688999
发表时间：
2002-12-24
影响因子：
11.1
作者：
Du, GG;Sandhu, B;MacLennan, DH
通讯作者：
MacLennan, DH
影响因子：
4.3
作者：
Carafoli, Ernesto
通讯作者：
Carafoli, Ernesto
DOI：
10.1073/pnas.48.9.1604
发表时间：
1962-01-01
影响因子：
11.1
作者：
DELUCA, HF;ENGSTROM, GW;RASMUSSEN, H
通讯作者：
RASMUSSEN, H
内膜的四十千克蛋白是线粒体钙Uniporter。
影响因子：
64.8
作者：
De Stefani, Diego;Raffaello, Anna;Teardo, Enrico;Szabo, Ildiko;Rizzuto, Rosario
通讯作者：
Rizzuto, Rosario