Protein Sequence Comparison Based on Physicochemical Properties and the Position-Feature Energy Matrix.
Protein Sequence Comparison Based on Physicochemical Properties and the Position-Feature Energy Matrix.
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基于理化性质和位置特征能量矩阵的蛋白质序列比较
DOI：
10.1038/srep46237
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发表时间：
2017-04-10
影响因子：
4.6
通讯作者：
Dehmer M
中科院分区：
文献类型：
--
作者：
Yu L;Zhang Y;Gutman I;Shi Y;Dehmer M
我们开发了一种新的基于位置特征的蛋白质序列模型，利用20个氨基酸的物理化学性质和图能量的测量。该方法强调序列的顺序信息，描述序列的局部动态分布，并由此得到特征B向量。然后，我们将相对熵应用于表示B向量的序列来度量它们的相似性/相异性。在这项研究中获得的数值结果表明，所提出的方法导致有意义的结果相比，如Clustal W的竞争对手。
We develop a novel position-feature-based model for protein sequences by employing physicochemical properties of 20 amino acids and the measure of graph energy. The method puts the emphasis on sequence order information and describes local dynamic distributions of sequences, from which one can get a characteristic B-vector. Afterwards, we apply the relative entropy to the sequences representing B-vectors to measure their similarity/dissimilarity. The numerical results obtained in this study show that the proposed methods leads to meaningful results compared with competitors such as Clustal W.