Phospholipase C-β in immune cells.
Phospholipase C-β in immune cells.
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DOI：
10.1016/j.jbior.2013.08.001
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发表时间：
2013-09
影响因子：
--
通讯作者：
Xiao, Wenbin
中科院分区：
文献类型：
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作者：
Kawakami, Toshiaki;Xiao, Wenbin
Great progress has recently been made in structural and functional research of phospholipase C (PLC)-β. We now understand how PLC-β isoforms (β1-β4) are activated by GTP-bound Gαq downstream of G protein-coupled receptors. Numerous studies indicate that PLC-βs participate in the differentiation and activation of immune cells that control both the innate and adaptive immune systems. The PLC-β3 isoform also interplays with tyrosine kinase-based signaling pathways, to inhibit Stat5 activation by recruiting the protein-tyrosine phosphatase SHP-1, with which PLC-β3 and Stat5 form a multi-molecular signaling platform, named SPS complex. The SPS complex has important regulatory roles in tumorigenesis and immune cell activation.
