Modeling the attenuation and failure of action potentials in the dendrites of hippocampal neurons.
Modeling the attenuation and failure of action potentials in the dendrites of hippocampal neurons.
复制标题
模拟海马神经元树突中动作电位的衰减和衰竭。
DOI：
10.1016/s0006-3495(96)79433-x
复制
发表时间：
1996
影响因子：
3.4
通讯作者：
M. Migliore
中科院分区：
文献类型：
--
作者：
M. Migliore
We modeled two different mechanisms, a shunting conductance and a slow sodium inactivation, to test whether they could modulate the active propagation of a train of action potentials in a dendritic tree. Computer simulations, using a compartmental model of a pyramidal neuron, suggest that each of these two mechanisms could account for the activity-dependent attenuation and failure of the action potentials in the dendrites during the train. Each mechanism is shown to be in good qualitative agreement with experimental findings on somatic or dendritic stimulation and on the effects of hyperpolarization. The conditions under which branch point failures can be observed, and a few experimentally testable predictions, are presented and discussed.
分泌神经末梢中 GABA 激活的氯离子通道。
DOI：
10.1126/science.8380942
发表时间：
1993
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Zhang,SJ;Jackson,MB
通讯作者：
Jackson,MB
影响因子：
2.5
作者：
MIGLIORE, M;COOK, EP;JOHNSTON, D
通讯作者：
JOHNSTON, D
影响因子：
2.5
作者：
SPRUSTON, N;JOHNSTON, D
通讯作者：
JOHNSTON, D