Contribution of adipocytes in the tumor microenvironment to breast cancer metabolism
Contribution of adipocytes in the tumor microenvironment to breast cancer metabolism
复制标题
肿瘤微环境中脂肪细胞对乳腺癌代谢的贡献
DOI：
10.1016/j.canlet.2022.215616
复制
发表时间：
2022-03-06
期刊：
影响因子：
9.7
通讯作者：
Sun, Li
中科院分区：
文献类型：
--
作者：
Lyu, Xiaodan;Zhang, Qian;Sun, Li
乳腺癌被认为是最常见的恶性肿瘤，具有进行广泛代谢重编程的深刻能力。在乳腺癌微环境中，高度可用的癌症相关脂肪细胞通过释放各种脂肪细胞因子和代谢物与癌细胞相互作用。肥胖也是这种方式的一个重要因素，其中脂肪组织在肿瘤组织附近的积累与乳腺癌的发病率、进展和转移的增加有关。由乳腺癌细胞和功能失调的脂肪组织之间的串扰引起的代谢变化包括葡萄糖、脂质和氨基酸代谢。因此，阻止乳腺癌细胞和功能失调的脂肪组织之间的这种相互作用可能会开发出一种有希望的乳腺癌治疗策略。本文综述了乳腺癌细胞与脂肪细胞之间的代谢变化。我们还回顾了旨在破坏这种相互作用的治疗方法的最新进展。
Breast cancer is considered the most common malignancy, with the profound ability to perform a wide range of metabolic reprogramming. Within the breast cancer microenvironment, highly available cancer-associated adipocytes interact with cancer cells by releasing various adipocytokines and metabolites. Obesity is also an important factor in this manner, where the accumulation of adipose tissue next to tumor tissue is linked to the increased incidence, progression, and metastasis of breast cancer. The metabolic changes caused by the crosstalk between breast cancer cells and dysfunctional adipose tissue include glucose, lipid, and amino acid metabolism. Thus, preventing this interaction between breast cancer cells and dysfunctional adipose tissue might develop a promising therapeutic strategy against breast cancer. This review focused on the metabolic changes responsible for inducing the crosstalk between breast cancer cells and adipocytes. We also reviewed the recent updates in therapeutics designed to disrupt this interaction.