Leuprolide acetate depot decreases the number of nucleolar organizer regions in uterine leiomyomata.
Leuprolide acetate depot decreases the number of nucleolar organizer regions in uterine leiomyomata.
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醋酸亮丙瑞林长效制剂可减少子宫平滑肌瘤中核仁组织区的数量。
DOI：
10.1016/s0015-0282(16)56177-9
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发表时间：
1993
影响因子：
6.7
通讯作者：
Friedman,AJ
中科院分区：
文献类型：
--
作者：
Barbieri,RL;Dilena,M;Chumas,J;Rein,MS;Friedman,AJ
有症状子宫肌瘤的女性在子宫肌瘤切除术前被随机分配接受 LA depot 或安慰剂 12 周。在子宫肌瘤切除术时获得的组织中评估每个细胞核的银染色核仁组织区（AgNOR）。与接受安慰剂治疗的女性相比，子宫肌瘤切除术前接受 LA depot 治疗的女性肌瘤组织中每个细胞核的 AgNOR 显着减少。醋酸亮丙瑞林长效制剂可能会减少肌瘤中增殖细胞的数量。
Women with symptomatic uterine myomas were randomized to receive LA depot or placebo for 12 weeks before myomectomy. Silver staining nucleolar organizer regions (AgNORs) per nuclei were assessed in the tissue obtained at the time of myomectomy. Myoma tissue from women treated with LA depot before myomectomy had significantly fewer AgNORs per nuclei than myoma tissue obtained from women treated with placebo. Leuprolide acetate depot may reduce the number of proliferating cells in myomas.