Prevalence of Allergic Disease in Foreign-Born American Children
Prevalence of Allergic Disease in Foreign-Born American Children
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DOI：
10.1001/jamapediatrics.2013.1319
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发表时间：
2013-06-01
期刊：
影响因子：
26.1
通讯作者：
Joks, Rauno
中科院分区：
文献类型：
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作者：
Silverberg, Jonathan I.;Simpson, Eric L.;Joks, Rauno
重要性：对变态反应性疾病流行病学的深入了解导致新的治疗和预防策略。目的：研究美国出生地与儿童变态反应性疾病患病率之间的关系，并确定长期居住在美国对变态反应性疾病的影响。设计，设置，参与者：对参加2007-2008年全国儿童健康调查的91642名0至17岁儿童发放的横断面问卷。暴露：出生地。主要结果和测量：过敏性疾病的患病率，包括哮喘、湿疹、花粉热和食物过敏。结果：在美国以外出生的儿童患任何特应性疾病的几率明显低于在美国出生的儿童（logistic回归OR，0.48; 95% CI，0.38-0.61），包括既往哮喘哮喘（0.34; 0.23 - 0.51）、湿疹（0.43; 0.30-0.61）、花粉热（0.39; 0.27-0.55）和食物过敏（0.60; 0.37-0.99）。在多变量模型中，包括年龄、性别、种族/民族、家庭年收入、居住在大都市地区和儿童搬迁到新地址的历史，儿童出生地和特应性障碍之间的关联仍然显着。在美国境外出生的儿童，其父母也在美国境外出生，与父母出生在美国的儿童相比，任何特应性疾病的几率都显着降低（P= 0.005）。在美国境外出生的儿童在美国居住超过10年，与居住仅0至2年的儿童相比，发生任何过敏性疾病的几率显着更高（校正OR，3.04; 95% CI，1.08-8.60），包括湿疹（4.93; 1.18-20.62; P=.03）和花粉症（6.25; 1.70-22.96）但不包括哮喘或食物过敏（P >=.06）.结论和相关性：在美国以外出生的儿童在美国居住10年后，过敏性疾病的患病率较低。
Importance: Improved understanding of allergic disease epidemiology lead to novel therapeutic and prevention strategies.Objectives: To study the association between US birthplace and prevalence of childhood allergic disease and to determine the effects of prolonged US residence on allergic disease.Design, Setting, Participants: Cross-sectional questionnaire distributed to 91 642 children aged 0 to 17 years enrolled in the 2007-2008 National Survey of Children's Health.Exposure: Place of birth.Main Outcome and Measure: Prevalence of allergic disease, including asthma, eczema, hay fever, and food allergies.Results: Children born outside the United States had significantly lower odds of any atopic disorders than those born in the United States (logistic regression OR, 0.48; 95% CI, 0.38-0.61), including ever-asthma (0.53; 0.39-0.72), current-asthma (0.34; 0.23-0.51), eczema (0.43; 0.30-0.61), hay fever (0.39; 0.27-0.55), and food aller-gies (0.60; 0.37-0.99). The associations between child's birthplace and atopic disorders remained significant in multivariate models including age, sex, race/ethnicity, annual household income, residence in metropolitan areas, and history of child moving to a new address. Children born outside the United States whose parents were also born outside the United States had significantly lower odds of any atopic disorders than those whose parents were born in the United States (P=.005). Children born outside the United States who lived in the United States for longer than 10 years when compared with those who resided for only 0 to 2 years had significantly higher odds of developing any allergic disorders (adjusted OR, 3.04; 95% CI, 1.08-8.60), including eczema (4.93; 1.18-20.62; P=.03) and hay fever (6.25; 1.70-22.96) but not asthma or food allergies (P >=.06).Conclusions and Relevance: Children born outside the United States have a lower prevalence allergic disease that increases after residing in the United States for 1 decade.