Effects of various antiplatelet drugs and defibrinating agent on experimental glomerulonephritis in rats.
Effects of various antiplatelet drugs and defibrinating agent on experimental glomerulonephritis in rats.
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各种抗血小板药物和除纤维剂对大鼠实验性肾小球肾炎的影响。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
T. Naruse
中科院分区：
文献类型：
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作者：
S. Ogawa;T. Naruse
免疫学方法诱导的两种实验性肾炎。Heymann型AIC-GN和NTN用抗凝剂治疗。给AIC-GN大鼠注射双嘧达莫、阿司匹林、噻氯匹定或巴曲酶14~28天，给NTN大鼠注射NTS前2天和注射后14~21天。只有每天服用12.5~50.0 mg/kg双嘧达莫的大鼠尿蛋白显著减少，而其他药物治疗的AIC-GN或NTN大鼠的蛋白尿均未见明显减少。在组织病理学上，用这些药物治疗的AIC-GN大鼠的光镜和电子显微镜发现没有改善，即使用双嘧达莫也是如此。另一方面，在NTN大鼠，注射NTS后30~60min处死大鼠肾脏的光镜和电子显微镜观察显示，每日给予56.4 mg/kg阿司匹林或50.0 mg/Tg三氯匹定的大鼠血小板聚集和肾小球炎症改变明显减少，但在注射NTS 2周后，阿司匹林和三氯匹定治疗组大鼠的肾脏损害与对照组相比无明显差异。在双嘧达莫预处理的大鼠中，没有观察到组织学改善。以上结果表明，潘生丁对蛋白尿的有利作用与其抗血小板活性无关，血小板聚集在AIC-GN和NTN大鼠肾脏病变的发生发展过程中不是必需的。(J Lab Clin Med 99：428,1982)
Two types of experimental GN induced by immunological procedures. Heymann-type AIC-GN and NTN, were treated with anticoagulant agents. Dipyridamole, aspirin, ticlopidine or batroxobin was administered either to rats with AIC-GN for 14 to 28 days or to NTN rats 2 days prior to injection with NTS and 14 to 21 days thereafter. A significant decrease in the amount of urinary protein was observed only in rats treated with 12.5 to 50.0 mg/kg dipyridamole daily, whereas no significant decrease in proteinuria was observed in either AIC-GN or NTN rats treated with the other agents. Histopathologically, no improvement in the light and electron microscopic findings was noted in AIC-GN rats treated with these agents, even with dipyridamole. On the other hand, in NTN rats, light and electron microscopic study of the kidneys from rats sacrificed 30 to 60 min after NTS injection revealed that platelet aggregation and inflammatory changes in the glomeruli were remarkable reduced in rats pretreated with 56.4 mg/kg aspirin or 50.0 mg/tg triclopidine daily, but no difference in the renal lesions between rats treated with aspirin or triclopidine and control animals were observed 2 weeks after NTS injection. No histological improvement was observed in rats pretreated with dipyridamole. It would be reasonable to conclude from these results that the favorable effect of dipyridamole on proteinuria is not related to its antiplatelet activity and that platelet aggregation is not essential to the development of renal lesions in rat AIC-GN and NTN. (J Lab Clin Med 99:428, 1982.)