Diabetes and depression: Global perspectives
Diabetes and depression: Global perspectives
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DOI：
10.1016/j.diabres.2010.01.024
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发表时间：
2010-03-01
影响因子：
5.1
通讯作者：
Ellis, Charles
中科院分区：
文献类型：
--
作者：
Egede, Leonard E.;Ellis, Charles
背景：糖尿病和抑郁症是高度流行的疾病，对健康结局有重大影响。本研究回顾了糖尿病患者中抑郁症的患病率、疾病负担、发病率、死亡率、费用以及有效治疗的证据。方法：对糖尿病与抑郁症关系的文献进行系统综述。从1966年到2009年在Medline上进行了全面的文献检索。对研究糖尿病和抑郁症之间关系的研究进行了综述。由于研究的范围广泛和异质性，没有进行正式的荟萃分析。相反，进行了定性的研究汇总。结果：糖尿病和抑郁症是与显著的发病率、死亡率和医疗费用相关的衰弱疾病。糖尿病患者并发抑郁与患者对治疗的依从性降低、代谢控制不良、并发症发生率高、生活质量下降、医疗使用和费用增加、残疾和生产力丧失增加以及死亡风险增加有关。结论：糖尿病和抑郁的共存与显著的发病率、死亡率和增加的医疗费用有关。临床护理的协调策略对于改善临床结果和减轻疾病负担是必要的。(C)2010爱思唯尔爱尔兰有限公司。保留所有权利。
Background: Diabetes and depression are highly prevalent conditions and have significant impact on health outcomes. This study reviewed the literature on the prevalence, burden of illness, morbidity, mortality, and cost of comorbid depression in people with diabetes as well as the evidence on effective treatments.Methods: Systematic review of the literature on the relationship between diabetes and depression was performed. A comprehensive search of the literature was performed on Medline from 1966 to 2009. Studies that examined the association between diabetes and depression were reviewed. A formal meta-analysis was not performed because of the broad area covered and the heterogeneity of the studies. Instead, a qualitative aggregation of studies was performed.Results: Diabetes and depression are debilitating conditions that are associated with significant morbidity, mortality, and healthcare costs. Coexisting depression in people with diabetes is associated with decreased adherence to treatment, poor metabolic control, higher complication rates, decreased quality of life, increased healthcare use and cost, increased disability and lost productivity, and increased risk of death.Conclusion: The coexistence of diabetes and depression is associated with significant morbidity, mortality, and increased healthcare cost. Coordinated strategies for clinical care are necessary to improve clinical outcomes and reduce the burden of illness. (C) 2010 Elsevier Ireland Ltd. All rights reserved.