Understanding the roles of stress granule during chemotherapy for patients with malignant tumors
Understanding the roles of stress granule during chemotherapy for patients with malignant tumors
复制标题
了解应激颗粒在恶性肿瘤患者化疗过程中的作用
DOI：
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Songqing Fan
中科院分区：
文献类型：
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作者：
Yuting Zhan;Haihua Wang;Hongmei Zheng;Yue Ning;Sile Liu;Yang Yang;Ming Zhou;Songqing Fan
应激颗粒组装（SGs）是一种保守的调节细胞应激下蛋白质合成的机制，在这种机制下，全局蛋白质的翻译被沉默，生存所需的选择性蛋白质合成得以维持。SG的形成赋予了生存优势和对恶性细胞的化疗抗性。靶向SG组装可能是克服原发性和获得性化疗耐药，提高疗效的潜在治疗策略。我们全面回顾了近年来国内外关于可能诱导SGs的药物及其机制的文献，回顾了SGs与耐药相关蛋白的关系，阐明了SG组装的调控途径和潜在靶点，并讨论了未来克服化疗耐药的方向。
The assembly of stress granules (SGs) is a conserved mechanism to regulate protein synthesis under cell stress, where the translation of global protein is silenced and selective protein synthesis for survival maintains. SG formation confers survival advantages and chemotherapeutic resistance to malignant cells. Targeting SG assembly may represent a potential treatment strategy to overcome the primary and acquired chemotherapeutic resistance and enhance curative effect. We conduct a comprehensive review of the published literatures focusing on the drugs that potentially induce SGs and the related mechanism, retrospect the relationship between SGs and drug resistance related proteins, illuminate the regulated pathways and potential targets for SG assembly, and discuss future directions of overcoming the resistance to chemotherapy.