Peanut-Skin Polyphenols, Procyanidin A1 and Epicatechin-(4β→6)-epicatechin-(2β→O→7, 4β→8)-catechin, Exert Cholesterol Micelle-Degrading Activity in Vitro
Peanut-Skin Polyphenols, Procyanidin A1 and Epicatechin-(4β→6)-epicatechin-(2β→O→7, 4β→8)-catechin, Exert Cholesterol Micelle-Degrading Activity in Vitro
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DOI：
10.1271/bbb.121023
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发表时间：
2013-06-01
影响因子：
1.6
通讯作者：
Mura, Kiyoshi
中科院分区：
文献类型：
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作者：
Tamura, Tomoko;Inoue, Naoko;Mura, Kiyoshi
我们在花生果皮中鉴定出表儿茶素-(4β-gt；6)-表儿茶素-(2-β-gt；O->；7，4-β->；8)-儿茶素(EEC)。EEC(三聚体)在体外表现出比原花青素A1(二聚体)更强的胆固醇胶束降解活性。因此，在我们之前的实验中，花生皮多酚对喂饲高胆固醇饮食的大鼠的高胆固醇血症的抑制作用可能主要是由于肠道中的胶束降解作用。
We identified epicatechin-(4 beta -> 6)-epicatechin-(2 beta -> O -> 7, 4 beta -> 8)-catechin (EEC) in the skin of the peanut (Arachis hypogaea L.). EEC (a trimer) showed more potent cholesterol micelle-degrading activity than procyanidin A1 (a dimer) did in vitro. The hypercholesterolemia suppressing effect of a peanut skin polyphenol on rats fed high-cholesterol diet in our preceding experiments might thus have been due primarily to a micelle degrading effect in the intestine.