Tunicamycin, a new antibiotic. 3. Reversal of the antiviral activity of tunicamycin by aminosugars and their derivatives.
Tunicamycin, a new antibiotic. 3. Reversal of the antiviral activity of tunicamycin by aminosugars and their derivatives.
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衣霉素，一种新型抗生素。
DOI：
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发表时间：
1971
期刊：
影响因子：
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通讯作者：
G. Tamura
中科院分区：
文献类型：
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作者：
A. Takatsuki;G. Tamura
衣霉素是一种含有氨基葡萄糖的抗生素，其抗病毒活性可被某些氨基糖及其衍生物部分逆转。N-乙酰基-D-葡萄糖胺、N-乙酰基-D-半乳糖胺、N-乙酰基-D-甘露糖胺、N-己酰基-D-葡萄糖胺和N-庚酰基-D-葡萄糖胺是所有测试的最潜在的竞争者。由于它们的毒性，作为衍生物是无效的。没有氨基糖衍生物的活性。氨基糖及其衍生物对衣霉素抗病毒活性的抑制作用是部分的，而任何糖或糖的任何组合都没有观察到完全的逆转作用。衣霉素的抗病毒活性，只有轻微的效果。
The antiviral activity of tunicamycin, an antibiotic containing glucosamine, was partially reversed with some aminosugars and their derivatives. N-Acetyl-D-glucosamine, N-acetyl-D-galactosamine, N-acetyl-D-mannosamine, and N-hexanoyl- and N-heptanoyl-D-glucosamines were the most potential competitors among all tested. were not effective as derivatives because of their toxicity. were not active as the aminosugar derivatives. Reversal of the antiviral activity of tunicamycin with aminosugars and their derivative was partial, and full reversal was not observed with any sugar or any combination of sugars examined. the antiviral activity tunicamycin, only a slight effect.