Maternal Vitamin D Deficiency Causes Sustained Impairment of Lung Structure and Function and Increases Susceptibility to Hyperoxia-induced Lung Injury in Infant Rats
Maternal Vitamin D Deficiency Causes Sustained Impairment of Lung Structure and Function and Increases Susceptibility to Hyperoxia-induced Lung Injury in Infant Rats
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DOI：
10.1165/rcmb.2019-0295oc
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发表时间：
2020-07-01
影响因子：
6.4
通讯作者：
Abman, Steven H.
中科院分区：
文献类型：
--
作者：
Mandell, Erica W.;Ryan, Sharon;Abman, Steven H.
妊娠期维生素D缺乏（VDD）与早产后呼吸系统疾病发病率和慢性肺病风险增加有关。然而，母体VDD对围产期肺结构和功能的直接影响以及母体VDD是否增加了高氧肺损伤的易感性尚不清楚。在本研究中，我们试图确定母体VDD是否足以损害肺结构和功能，以及VDD是否会增加高氧对发育中的大鼠肺的影响。4周大的大鼠被喂食VDD食物，并被安置在一个屏蔽紫外线a /B光的房间里，以达到25-羟基维生素D的浓度
Vitamin D deficiency (VDD) during pregnancy is associated with increased respiratory morbidities and risk for chronic lung disease after preterm birth. However, the direct effects of maternal VDD on perinatal lung structure and function and whether maternal VDD increases the susceptibility of lung injury due to hyperoxia are uncertain. In the present study, we sought to determine whether maternal VDD is sufficient to impair lung structure and function and whether VDD increases the impact of hyperoxia on the developing rat lung. Four-week-old rats were fed VDD chow and housed in a room shielded from ultraviolet A/B light to achieve 25-hydroxyvitamin D concentrations