The effectiveness of unitization in mitigating age-related relational learning impairments depends on existing cognitive status.
The effectiveness of unitization in mitigating age-related relational learning impairments depends on existing cognitive status.
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DOI：
10.1080/13825585.2016.1158235
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Ryan JD
中科院分区：
文献类型：
--
作者：
D'Angelo MC;Smith VM;Kacollja A;Zhang F;Binns MA;Barense MD;Ryan JD
横向构图（TP）任务中项目之间的绑定关系依赖于海马及其扩展网络的完整性。老年人TP学习受损，对应于年龄相关的海马体积减少。单位化是一种训练策略，可以通过减少对依赖于记忆的关系绑定的依赖和增加对融合表征的依赖来减轻健忘症中的TP损伤。在这里，我们研究了健康的老年人和那些表现出认知能力下降的早期迹象的人是否也会从单元化中受益。虽然这两组老年人的神经心理学表现在健康范围内，他们的TP学习不同的标准和统一的训练条件下。标准训练下TP学习受损的健康老年人受益于单元化训练。未通过蒙特利尔认知评估（莫卡）的老年人在标准条件下表现出更大的障碍，并且没有证据表明单元化有所改善。这些人未能从单位化中获益可能是通过莫卡的老年人中未发现的早期缺陷的结果。
Binding relations among items in the transverse patterning (TP) task is dependent on the integrity of the hippocampus and its extended network. Older adults have impaired TP learning, corresponding to age-related reductions in hippocampal volumes. Unitization is a training strategy that can mitigate TP impairments in amnesia by reducing reliance on hippocampal-dependent relational binding and increasing reliance on fused representations. Here we examined whether healthy older adults and those showing early signs of cognitive decline would also benefit from unitization. Although both groups of older adults had neuropsychological performance within the healthy range, their TP learning differed both under standard and unitized training conditions. Healthy older adults with impaired TP learning under standard training benefited from unitized training. Older adults who failed the Montreal Cognitive Assessment (MoCA) showed greater impairments under standard conditions, and showed no evidence of improvement with unitization. These individuals’ failures to benefit from unitization may be a consequence of early deficits not seen in older adults who pass the MoCA.