Pallidal and caudate volumes correlate with walking function in multiple sclerosis
Pallidal and caudate volumes correlate with walking function in multiple sclerosis
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DOI：
10.1016/j.jns.2015.04.041
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发表时间：
2015-07-15
影响因子：
4.4
通讯作者：
Benedict, Ralph H. B.
中科院分区：
文献类型：
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作者：
Motl, Robert W.;Hubbard, Elizabeth A.;Benedict, Ralph H. B.
背景：行走功能障碍在多发性硬化症（MS）中很常见。丘脑和基底神经节似乎与行走表现有重要的联系。这些皮层下灰质（SGM）结构的步行功能障碍的贡献是知之甚少MS。目的：本研究探讨了丘脑和基底神经节与MS的步行结果之间的关联。方法：我们招募了61名MS患者谁接受了脑MRI，并完成了6分钟的步行（6 MW）和定时25英尺的步行（T25FW）。从三维T1加权结构脑图像计算丘脑、尾状核、壳核和苍白球的体积以及全脑白色物质（WM）和灰质（GM）。我们使用双变量相关性（r）和偏相关性（pr）检查相关性，控制年龄，MS临床病程，全脑WM和GM体积。我们进一步进行了分层线性回归（hierarchical linear regression，HLM），以确定与行走能力相关性最强的SGM。6MW和T25FW与丘脑体积显著相关（r = 0.382 & 0.383）、尾状核（r = 0.388 & 0.416）、苍白球（r = 0.457 & 0.457）和壳核（r = 0.258 & 0.293）在双变量相关中。6 MW和T25 FW与尾状核（pr = 0.243 & 0.312）和苍白球（pr = 0.321 & 0.345）体积在偏相关中保持显著相关。苍白球体积是6 MW（β = .39）和T25FW（β = .40）性能的最强SGM相关性。结论：我们提供了可能的SGM结构的新证据，特别是苍白球和尾状核，作为MS行走性能的相关性。（C）2015 Elsevier B.V.保留所有权利。
Background: Walking dysfunction is common in multiple sclerosis (MS). The thalamus and basal ganglia seemingly have important associations with walking performance. The contribution of these subcortical gray matter (SGM) structures for walking dysfunction is poorly understood in MS.Purpose: This study examined associations among volumes of the thalamus and basal ganglia with walking outcomes in MS.Method: We enrolled 61 MS patients who underwent brain MRI and completed the 6-minute walk (6 MW) and timed 25-foot walk (T25FW). Volumes of the thalamus, caudate, putamen, and pallidum as well as whole-brain white matter (WM) and gray matter (GM) were calculated from 3D T1-weighted structural brain images. We examined associations using bivariate correlations (r) and partial correlations (pr) that controlled for age, MS clinical course, and whole-brain WM and GM volumes. We further performed hierarchical linear regression (HLR) for identifying the strongest SGM correlate of walking performance.Results: The 6 MW and T25FW correlated significantly with volumes of the thalamus (r's = .382 & .383), caudate (r's = .388 & .416), pallidum (r's = .457 & .457), and putamen (r's = .258 & .293) in bivariate correlations. The 6 MW and T25FW remained significantly correlated with caudate (pr's = .243 & .312) and pallidum (pr's = .321 & .345) volumes in partial correlations. Pallidum volume was the strongest SGM correlate of 6 MW (beta = .39) and T25FW (beta = .40) performance in HLR.Conclusion: We provide novel evidence of possible SGM structures, particularly the pallidum and perhaps caudate, as correlates of walking performance in MS. (C) 2015 Elsevier B.V. All rights reserved.