On the use of Plasma Proteins as Indicators of the Metabolic Effects of Combined Oral Contraceptives
On the use of Plasma Proteins as Indicators of the Metabolic Effects of Combined Oral Contraceptives
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关于使用血浆蛋白作为复方口服避孕药代谢作用的指标
DOI：
10.3109/00016348209155359
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发表时间：
1982
影响因子：
4.3
通讯作者：
K. Stéffensen
中科院分区：
文献类型：
--
作者：
G. Cullberg;Per;G. Lindstedt;K. Stéffensen
抽象。炔雌醇（EE，17α-乙炔基-1，3，5（10）-雌三烯-3，17 β-二醇）30 μg/天，联合150μg/天的去氧孕烯（顺2969，17 α-乙炔基-18-甲基-11-亚甲基-4-雌烯-17 β-醇）或左炔诺孕酮（17α-乙炔基-18-甲基-4-雌烯-17 β-醇-3-酮），给予两组10名健康女性，她们在研究前3个月内没有接受激素治疗。以3个21天周期（间隔7天）给予制剂。在给药前和第三个给药期结束时采集血样。通过电免疫分析法分析血清性激素结合球蛋白（SHBG）、血浆铜蓝蛋白、类粘蛋白、C1-酯酶抑制剂和C4，并测定皮质醇结合能力的转皮质素。使用对双氢睾酮（DHT）具有约20%交叉反应性的抗血清，通过二氯甲烷提取物的放射免疫测定法测定血清睾酮。
Abstract. Ethinylestradiol (EE, 17α‐ethynyl‐1,3,5(10)‐es‐tratriene‐3,17β‐diol) 30 μg daily, in combination with 150μg per day of desogestrel (Org 2969,17α‐ethynyl‐18‐methyl‐11‐methylene‐4‐estrene‐17β‐ol) or levonorgestrel (17α‐ethynyl‐18‐methyl‐4‐estrene‐17β‐ol‐3‐one), was administered to two groups of 10 healthy human women who had been without hormonal treatment during 3 months prior to the study. The preparations were given for three 21‐day cycles with 7‐day intervals. Blood samples were taken before treatment and at the end of the third treatment period. Serum sex‐hormone binding globulin (SHBG), ceruloplasmin, ornsomucoid, C1‐esterase inhibitor and C4 were analyzed by electroimmunoassay and transcortin was assayed as cortisol‐binding capacity. Serum testosterone was assayed by radioimmunoassay of methylenedichloride extracts using an antiserum with about 20% cross‐reactivity for dihydrotestosterone (DHT).