PCBS AS ENVIRONMENTAL ESTROGENS - TURTLE SEX DETERMINATION AS A BIOMARKER OF ENVIRONMENTAL CONTAMINATION
PCBS AS ENVIRONMENTAL ESTROGENS - TURTLE SEX DETERMINATION AS A BIOMARKER OF ENVIRONMENTAL CONTAMINATION
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DOI：
10.2307/3432139
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发表时间：
1994-09-01
影响因子：
10.4
通讯作者：
MCLACHLAN, JA
中科院分区：
文献类型：
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作者：
BERGERON, JM;CREWS, D;MCLACHLAN, JA
多氯联苯（PCBs）是一种分布广泛的低浓度环境污染物，具有免疫抑制和致畸等不良健康效应。越来越多的证据表明，某些多氯联苯化合物能够干扰鱼类、鸟类和哺乳动物（包括人类）的生殖和内分泌功能，特别是在发育期间。对这些化合物改变生殖功能的机制的研究表明，这些化合物可能具有雌激素活性，从而改变性分化。在这里，我们证明了一些多氯联苯的雌激素效应逆转性腺性别的爬行动物物种，表现出温度依赖性的性别决定。
Polychlorinated biphenyls (PCBs) are wide-spread, low-level environmental pollutants associated with adverse heath effects such as immune suppression and teratogenicity. There is increasing evidence that some PCB compounds are capable of disrupting reproductive and endocrine function in fish, birds, and mammals, including humans, particularly during development. Research on the mechanism through which these compounds act to alter reproductive function indicates estrogenic activity, whereby the compounds may be altering sexual differentiation. Here we demonstrate the estrogenic effect of some PCBs by reversing gonadal sex in a reptile species that exhibits temperature-dependent sex determination.