Relevance of TNF-α in the context of other inflammatory cytokines in the progression of diabetic nephropathy.
Relevance of TNF-α in the context of other inflammatory cytokines in the progression of diabetic nephropathy.
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DOI：
10.1038/ki.2015.250
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发表时间：
2015-10
影响因子：
19.6
通讯作者：
Kanwar YS
中科院分区：
文献类型：
--
作者：
Sun L;Kanwar YS
最近在糖尿病肾病发病机制中发展的辅助范例包括亚临床“微炎症”，伴随巨噬细胞的流入和随之产生的无数促炎细胞因子和随后的肾损伤。在各种促炎细胞因子中，TNF-α引起了最多的关注，因为它放大了细胞因子的炎症网络，导致糖尿病肾病进展的恶化。Awad等人的随附文章检查了TNF-α在实验性糖尿病肾病发病机制中的作用。
An ancillary paradigm that has evolved recently in the pathogenesis of diabetic nephropathy includes subclinical “micro-inflammation” with influx of macrophages and consequential generation of myriad pro-inflammatory cytokines and ensuing kidney damage. Among various pro-inflammatory cytokines TNF-α has attracted the most attention since it amplifies the inflammatory network of cytokines leading to worsening of the progression of diabetic nephropathy. The accompanying article by Awad et al. examines the role of TNF-α in the pathogenesis of experimental diabetic nephropathy.