Abnormal lung cytokine synthesis by immunodeficient T cells in murine AIDS-associated interstitial pneumonitis.
Abnormal lung cytokine synthesis by immunodeficient T cells in murine AIDS-associated interstitial pneumonitis.
复制标题
小鼠艾滋病相关间质性肺炎中免疫缺陷 T 细胞合成异常肺细胞因子。
DOI：
10.1111/j.1749-6632.1996.tb32566.x
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发表时间：
1996
影响因子：
5.2
通讯作者：
Gillespie,M
中科院分区：
文献类型：
--
作者：
Cohen,D;Fitzpatrick,E;Hartsfield,C;Avdiushko,M;Gillespie,M
艾滋病毒携带者的肺部并发症是艾滋病发病率和死亡率的重要原因。虽然各种机会性病原体的肺部感染在艾滋病期间很常见，但在艾滋病和艾滋病相关并发症期间，也经常观察到一些非感染性肺部并发症。这些非感染性疾病包括心肌病、心包和胸腔积液、肺血栓栓塞症、肺心病和高血压性肺血管疾病。在艾滋病流行期间积累的I-‘证据表明，间质性肺炎(IP)也是成人和儿童HIV感染的主要肺部并发症。*-“淋巴细胞性间质性肺炎(LLIP)在成人艾滋病患者中罕见，其组织学特征是淋巴细胞、浆细胞和免疫母细胞弥漫性侵入肺泡间隔和细支气管区(1-296)。但在儿童艾滋病中发现的病例超过50%。对嘴唇细胞浸润物的分析表明，在患者的活检组织中，可以发现不同比例的CD4+T细胞、CD8+T细胞和B细胞。这些淋巴细胞中的许多似乎在SITR中被激活，这要么是由于肺部的抗原特异性反应，要么是由于不明的非特异性刺激。LIP期间可出现肺功能障碍，表现为轻度至中度低氧血症和一氧化碳弥散能力下降。“)此外，LIP在儿童中往往更严重，在某些情况下会导致病程后期的呼吸衰竭。15与LIP相反，非特异性间质性肺炎(NIP)在成人中比在感染艾滋病毒的儿童中更常见，在高达38%的成年艾滋病患者中有记录。22 NIP与LIP的不同之处在于，NIP的淋巴细胞浸润通常较轻，并与中度水肿、纤维蛋白沉积、
Pulmonary complications in HIV+ individuals represent a significant cause of morbidity and mortality in AIDS. While pulmonary infections by a variety of opportunistic pathogens are common during AIDS, a number of noninfectious complications of the lungs also are frequently observed during both AIDS and AIDS-related complex. These noninfectious disorders include cardiomyopathy, pericardial and pleural effusions, pulmonary thromboembolism, cor pulmonale, and hypertensive pulmonary vascular disease. I-'Evidence accumulated during the AIDS epidemic has indicated that interstitial pneumonitis (IP) also is a major pulmonary complication of HIV infections in both adults and children.*-" Lymphocytic interstitial pneumonitis (LIP), which is characterized histologically by diffuse infiltration of the alveolar septae and peribronchiolar areas by lymphocytes, plasma cells, and immunoblasts, occurs infrequently in adult AIDS patients (1-296). but is found in pediatric AIDS in more than 50% of the case^.^^.^^ Analysis of the cellular infiltrate in LIP indicates that CD4+ T cells, CD8+ T cells, and B cells can be found in varying proportions in biopsies from patients. lh-I9 Many of these lymphocytes appear to be activated in sitrr, due either to an antigen-specific response in the lungs or to undefined nonspecific stimulation. Pulmonary dysfunction can occur during LIP as indicated by mild to moderate hypoxemia and a decrease in diffusing capacity for carbon monoxide.")~? 0~ 2'In addition, LIP tends to be more severe in children, leading in some cases to respiratory failure late in the course of disease. l5In contrast to LIP, nonspecific interstitial pneumonitis (NIP) occurs more frequently in adults than in children with HIV, being documented in up to 38% of adult AIDS patients.". 22 NIP contrasts with LIP in that lymphocytic infiltration usually is milder in NIP and is associated with moderate edema, fibrin deposition,