Three-dimensional pancreas organogenesis models.
Three-dimensional pancreas organogenesis models.
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DOI：
10.1111/dom.12720
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发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Grapin-Botton A
中科院分区：
文献类型：
--
作者：
Grapin-Botton A
三维培养的重新发现导致了适用于人体组织的器官生物发生、体内平衡和疾病模型的发展。最近蓬勃发展的所谓类器官作为细胞系或培养板底部生长的原代细胞与体内实验之间的有价值的模型桥梁。虽然不能概括器官生理学的所有方面，但在培养皿中产生的微型器官是胰腺的有用模型，从胚胎祖细胞、成体细胞、肿瘤细胞和干细胞开始。本文综述了目前可用的系统及其与胰腺、β细胞和包括糖尿病在内的几种胰腺疾病研究的相关性。我们讨论了未来研究人类胰腺发育和功能、发展糖尿病模型和生产治疗细胞的预期发展。
A rediscovery of three-dimensional culture has led to the development of organ biogenesis, homeostasis and disease models applicable to human tissues. The so-called organoids that have recently flourished serve as valuable models bridging between cell lines or primary cells grown on the bottom of culture plates and experiments performed in vivo. Though not recapitulating all aspects of organ physiology the miniature organs generated in a dish are useful models emerging for the pancreas, starting from embryonic progenitors, adult cells, tumor cells and stem cells. This review focusses on the currently available systems and their relevance to the study of the pancreas, of β-cells and of several pancreatic diseases including diabetes. We discuss the expected future developments for studying human pancreas development and function, for developing diabetes models and for producing therapeutic cells.
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