Neuroendocrine aspects of primary endogenous depression XV: Mathematical modeling of nocturnal melatonin secretion in major depressives and normal controls
Neuroendocrine aspects of primary endogenous depression XV: Mathematical modeling of nocturnal melatonin secretion in major depressives and normal controls
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DOI：
10.1016/s0165-1781(96)02937-x
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发表时间：
1997-03-24
影响因子：
11.3
通讯作者：
Rubin, RT
中科院分区：
文献类型：
--
作者：
Sekula, LK;Lucke, JF;Rubin, RT
我们先前报道了基于24小时内30分钟的血液采样，与23名匹配的正常女性对照受试者相比，23名女性明确的内源性抑郁症患者的平均夜间血清褪黑激素（MEL）浓度有升高的趋势，而15名男性抑郁症患者与其对照组相比无显著差异（Rubin等人，1992年）。在两组患者与对照组中，也有MEL上升时间提前约30分钟和MEL峰值时间延迟约90分钟的趋势。由于在该研究中未估计MEL分泌的偏移，因此无法确定MEL分泌的总持续时间。为了进一步描绘夜间MEL分泌曲线，我们通过线性Beta模型（Beta函数的四参数适应）对MEL数据进行建模。一个参数解释基线（昼夜）MEL浓度，两个解释夜间分泌曲线上升和下降阶段的形状，第四个解释曲线下面积。该模型允许估计夜间MEL分泌的开始、峰值和结束时间。与对照组相比，女性抑郁症患者的平均夜间MEL浓度也有升高的趋势。除了夜间MEL偏移时间外，女性或男性的分泌开始或峰值时间均无显著的患者对照差异：女性患者的偏移时间比对照组晚约40分钟;男性患者中不存在这种差异。将男性和女性合并分析，患者和对照组之间的夜间MEL偏移时间差异仅达到显著性（P <0.05）。线性β模型似乎令人满意地拟合MEL数据，并提供MEL分泌的激活阶段的起始、峰值和偏移时间的估计值。该模型可能适用于更严重的倾斜24小时激素分泌曲线，如促肾上腺皮质激素和皮质醇。(C)1997 Elsevier Science爱尔兰有限公司
We previously reported a trend toward a higher mean nocturnal serum melatonin (MEL) concentration, based on 30-min blood sampling over 24 h, in 23 female definite endogenous depressives compared to 23 matched normal female control subjects, and no significant difference in 15 male depressives compared to their controls (Rubin et al., 1992). In both groups of patients vs. their controls, there also were trends toward an earlier MEL rise time, by about 30 min, and a later MEL peak time, by about 90 min. Because the offset of MEL secretion was not estimated in that study, the total duration of MEL secretion could not be determined. To further delineate the nocturnal MEL secretion curve, we modeled the MEL data by a linear-Beta model, a four-parameter adaptation of the Beta function. One parameter accounted for baseline (diurnal) MEL concentration, two accounted for the shapes of the ascending and descending phases of the nocturnal secretion curve, and the fourth accounted for the area under the curve. The model permitted estimation of the start, peak, and end times of nocturnal MEL secretion. There again was a trend toward a higher mean nocturnal MEL concentration in the female depressives compared to their matched controls. There were no significant patient-control differences in secretion onset or peak times in either the women or the men except for nocturnal MEL offset time: the female patients had a trend toward a later offset time, by about 40 min, than their controls; this difference was not present in the men. With women and men analyzed together, the difference in nocturnal MEL offset time between patients and controls just reached significance (P < 0.05). The linear-Beta model appears to satisfactorily fit the MEL data and provides estimators of the onset, peak, and offset times of the activation phase of MEL secretion. This model may be applicable to more severely skewed 24-h hormone secretion curves, such as ACTH and cortisol. (C) 1997 Elsevier Science Ireland Ltd.