POSTNATAL INFECTIVITY OF HEPATITIS-B SURFACE ANTIGEN-CARRIER MOTHERS
POSTNATAL INFECTIVITY OF HEPATITIS-B SURFACE ANTIGEN-CARRIER MOTHERS
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DOI：
10.1093/infdis/147.2.185
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发表时间：
1983-01-01
影响因子：
6.4
通讯作者：
HWANG, LY
中科院分区：
文献类型：
--
作者：
BEASLEY, RP;HWANG, LY
本文对105例B肝炎表面抗原携带者的母亲所生的2 ~ 3岁儿童进行了B肝炎病毒（HBV）感染率的测定。儿童在出生时给予B型肝炎免疫球蛋白（HBIG），在某些情况下，3个月和6个月。后来，以防止HBV感染。HBIG剂量的被动抗体在3-4个月内消失。12个月时HBV标志物阴性的婴儿。并分析随后的感染与母亲中E系统标记物的关系。平均超过17.5个月。随访时，38.1%的婴儿感染，年发病率为26.0%。母亲B肝炎e抗原（HBeAg）阳性的患儿发病率最高（57.1%），母亲HBeAg和抗-HBe均阴性的患儿发病率居中（20.4%），母亲抗-HBe阳性的患儿发病率最低（11.3%）。
The incidence of hepatitis B virus (HBV) infections during the 2nd and 3rd yr of life was determined for 105 children whose mothers were carriers of hepatitis B surface antigen. Children were given hepatitis B immune globulin (HBIG) at birth and in some instances 3 and 6 mo. later to protect against HBV infection. Passive antibodies from the dose of HBIG disappeared in 3-4 mo. Infants negative for HBV markers at 12 mo. were selected and subsequent infections were analyzed in relation to the e system markers in the mother. Over an average of 17.5 mo. of follow-up, 38.1% of the infants became infected, an annual incidence rate of 26.0%. The rate was highest for children whose mothers were positive for hepatitis B e antigen (HBeAg) (57.1%), moderate for those whose mothers were negative for HBeAg and antibody to HBeAg (anti-HBe) (20.4%) and lowest for those whose mothers were positive for anti-HBe (11.3%).